3. Cell Membrane Flashcards

1
Q

The resolution limit for light microscope is ____?

A

0.1um

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2
Q

“unit” membrane concept

A

-is trilaminar, consisting of protein and lipid

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3
Q

What chemical is used to fix plasma membranes?

A

OsO4

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4
Q

Osmium tetraoxide interact with the _______ portions of the phospholipid molecules of the unit membrane.

A

Hydrophilic

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5
Q

What are the 3 main classes of lipids in cell membrane?

A
  1. Phospholipids
  2. Sphingolipids
  3. Cholesterol
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6
Q

Glycolipids are positioned where on the cell membrane?

A

-only within the outer of the lipid bilayers with their carbohydrate moieties exposed on the cell surface.

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7
Q

What type of protein can be easily extracted with a salt solution?

A

peripheral proteins

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8
Q

What type of protein needs a detergent to be extracted from the cell membrane?

A

Integral proteins

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9
Q

Ion channels are formed by what type of protein?

A

Multi-pass integral protein

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10
Q

Receptors are typically formed by what type of protein?

A

Single-pass integral protein

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11
Q

Can lipids move in the plane of the membrane? Does it require energy?

A

Yes! But it does NOT require energy.. Simple diffusion or Brownian motion.

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12
Q

Does movement of a lipid from one leaflet to another require energy?

A

Yes

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13
Q

______ facilitate ATP dependent movement of a lipid from one leaflet to the other.

A

Flippases

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14
Q

Do membrane proteins connect to microtubules?

A

NO!

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15
Q

The membrane proteins that are anchored to the cytoskeleton use adaptor proteins like _______ to then connect to actin microfilaments.

A

ankyrin

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16
Q

Can proteins flip-flop in the membrane?

A

No

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17
Q

(T/F) Most membrane proteins are restricted in their lateral diffusion by attachment to cytoskeletal componets and membrane features.

A

True

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18
Q

______ are elongated motile processes with a highly organized microtubluar core.

A

Cilia

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19
Q

Cilia are inserted into ______.

A

Basal bodies

20
Q

The microvilli complex on the surface of a cell or series of epithelial cells is also called the ________ when examined at lower magnification.

A

Brush or striated boarder

21
Q

A filamentous coat of variable thickness covering the microvillus is called what?

A

glycocalyx (contains glycoproteins)

22
Q

Within the microvilli are clusters of 20-30 ___________.

A

actin microfilaments

23
Q

the basal ends of these microfilaments (in microvilli) intermingle with microfilaments of the ________ just beneath the microvilli.

A

terminal web

24
Q

Stereocilia are only found in the __________.

A

epidydimus

25
Q

Do stereocilia move or not move?

A

Do NOT move.

26
Q

What is the process of small invaginations of the cell membrane form and entrap extracellular fluid?

A

Pinocytosis

27
Q

A molecule with high affinity for a receptor

A

ligand

28
Q

The coating on the cytoplasmic surface of the membrane is composed of several polypeptides, the major one being __________.

A

clathrin

29
Q

Receptor-mediated endocytosis and coated vesicles is called what?

A

Absorptive phase

30
Q

_________ and __________ are specialized for incorporating and removing foreign bacteria, protozoa, fungi, damaged cells and un-needed extracellular constituents.

A

Macrophages and PMN leukocytes

31
Q

A macrophage eating a pathogen is called what?

A

receptor faciliated phagocytosis

32
Q

What type of secretion is spontaneous exocytosis?

A

Constitutive secretion

33
Q

What type of secretion is triggered by a hormone or neurotransmitter

A

Regulated secretion

34
Q

Discharge of secretory granule contents involves _______ and _________.

A

Ca++ ions, and requires energy (ATP and GTP)

35
Q

Zonula occludens is also known as __________?

A

Tight junction

36
Q

Zonula adherens is also known as __________?

A

Adherens junction

37
Q

Macula Adherens is also known as __________?

A

Desmosome

38
Q

Is a gap junction functional or structural membrane connection?

A

functional

39
Q

What forms the junctional complex?

A

Zonula occludens and Zonula adherens

40
Q

Gap junctions are a collection of _________, which are made up of proteins called _________.

A
  • connexons

- connexins

41
Q

Cell- cell adhesion is done through homophilic and herterophilic interations of what?

A

proteins (cadherins, Ig-superfamily, integrins and selectins)

42
Q

Since cadeherins are involved in connecting the two cells together makes the cell junction either an adherens junction or a desmosome but since ______ is involved within the cell then it can ONLY be an adherens junction

A

Actin

43
Q

Signaling that act on neighboring cells only

A

paracrine

44
Q

signaling that acts on the same cell that produced the messenger molecule.

A

autocrine

45
Q

signaling carried through blood to distant site to ac on cells

A

endocrine