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Flashcards in Topic 6 Deck (42)
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1
Q

Changes in the dissociation reaction can affect

A

pH of solution

2
Q

Temperature affects

A

dissociation of molecules in solution

3
Q

decreased temperature produces

A
  • decrease in energy which produces
  • decrease in dissociation which produces
  • decrease in concentration of all IONIZED components
  • Equilibrium of dissociation moves to the LEFT
4
Q

At equilibrium, the pH produced is called the

A

pH of neutrality

At 27C, the pH of neutrality is 7.0

5
Q

Henry’s law formula

A

Dissolved = Solubility x Partial Pressure

6
Q

Solubility

CO2 @ 37 degrees C =

A

0.06 mls CO2/100 mls bld/mmHg

7
Q

Solubility

O2 @ 37 degrees C =

A

0.003 mls O2/100 mls bld/mmHg

8
Q

How is CO2 moved from tissue to lungs

A

Dissolved
Bound to hemoglobin
As HCO3-

9
Q

Haldane Effect

A

Represents affect of PO2 on ability of CO2 to bind to hemoglobin

10
Q

Content ≈

A

Solubility x PP

11
Q

PP ≈

A

Content / Solubility

12
Q

Solubility is inversely proportional to

A

temperature

13
Q

Temperature increases, then Solubility

A

decreases

14
Q

Temperature decreases, then Solubility

A

increases

15
Q

change the pH of blood in a “closed” system via option A=

A

Change CO2 content and keep temp constant

16
Q

change the pH of blood in a “closed” system via option B=

A

Change temp and keep total CO2 content constant

17
Q

change the pH of blood in a “closed” system via option C=

A

Change CO2 content and change temp

18
Q

Option A: Increase total CO2 content by ADDING additional CO2 will cause

A

pCO2 will increase

pH will decrease

19
Q

Option A: Decrease total CO2 content by REMOVING CO2 will cause

A

pCO2 will decrease

pH will increase

20
Q

Option A: No change in temperature means

A

No change in solubility

No change in acid-base disassociation equilibriums

21
Q

Option B: Increase temperature will cause

A

Drive acid-base disassociation equilibrium to the right
[H+] will increase
pH will decrease

22
Q

Option B: Decrease temperature will cause

A

Drive acid-base disassociation equilibrium to the left
[H+] will decrease
pH will increase

23
Q

Option B: No change in total CO2 content means

A

pCO2 WILL change due to change in solubility, BUT NO CORRESPONDING change in pH

24
Q

Option C: Change total CO2 content will cause

A

pCO2 will change producing an inverse change in pH

25
Q

Option C: Change temperature will cause

A

Disassociation equilibrium will change causing a corresponding increase or decrease in [H+]

26
Q

Option C Result will be a

A

bigger/smaller change in pH than might be expected

27
Q

Blood in a closed system (no change in CO2 content)…

Temperature Increases … then Gas solubility

A

decrease

28
Q

Blood in a closed system (no change in CO2 content)…

Temperature Increases … then Gas partial pressure

A

increase

29
Q

Blood in a closed system (no change in CO2 content)…

Temperature Increases … then gas pressure is _____ than the starting gas pressure

A

higher

30
Q

Blood in a closed system (no change in CO2 content)…

Temperature Increases … then Equilibrium of the water dissociation shifts to the

A

right

31
Q

Blood in a closed system (no change in CO2 content)…

Temperature Increases … then pH will

A

decrease

32
Q

Blood in a closed system (No change in CO2 content)…

Temperature Decreases… then Gas solubility

A

increases

33
Q

Blood in a closed system (No change in CO2 content)…

Temperature Decreases… then Gas partial pressure

A

decreases

34
Q

Blood in a closed system (No change in CO2 content)…

Temperature Decreases… then gas pressure is ____ than the starting gas pressure

A

lower

35
Q

Blood in a closed system (No change in CO2 content)…

Temperature Decreases… then Equilibrium of the water dissociation shifts to the

A

left

36
Q

Blood in a closed system (No change in CO2 content)…

Temperature Decreases… then pH will

A

increase

37
Q

Blood Gas Determination Via Lab=

A
  1. Draw sample (Remove all air from sample – Cap tightly – Place in cup of ice)
  2. Blood from sample injected into analyzer
  3. Analyzer WARMS sample to 37C
  4. Analyzer determines the pO2, pCO2, and pH at 37C
38
Q

Blood gas analyzers heat the blood to 37C before measuring parameters- effects pO2 and pCO2 how

A

Decreases solubility of gases in sample so PO2 and PCO2 will be artificially high at 37C

39
Q

Blood gas analyzers heat the blood to 37C before measuring parameters- effects pH how

A

Pushed HOH equation to right so pH will be artificially low at 37C

40
Q

Uncorrected gases=

A

Report gas values determined at 37C

41
Q

Corrected gases=

A

Report gas values measured at 37C then corrected back to actual body temperature

42
Q

Temperature Correction of Blood Gases

-Patient temp is 25 so analyzer will WARM the sample- which means that…

A

pH will be lower than expected (0.0147 per degree)
CO2 will be higher than expected
O2 will be higher than expected