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POM 3 G: IMMUNOLOGY AND INFECTION > 3.2 Lymphoid Tissue > Flashcards

3.2 Lymphoid Tissue Flashcards

1
Q

Lymphatic system is comprised of

A

Lymphatic vessels

Secondary lymphoid tissue

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2
Q

Lymph vessel example

A

Thoracic duct

Axillary nodes

Intercostal vesses

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3
Q

Lymphoid tissue is comprised of

A

Primary
Secondary
Tertiary

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4
Q

Primary lymphoid tissue

A

Make up primary lymphoid organs: the site of lymphopoiesis (production of lymphocytes)

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5
Q

Lymphocyte examples

A

B cells
T cells
NK Cells

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6
Q

Primary lymphoid organs examples

A

Thymus

Bone marrow

Fetal liver

Site of lymphopoiesis

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7
Q

What comprise the adaptive immune response

A

B cells and t cells

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8
Q

Hallmarks (ability) of the adaptive immune response

A

Specifity- vast range of unique b and T cell receptors

Memory- rapid expansion in response to second encountee

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9
Q

Humoral response relates to

A

B lymphocytes

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10
Q

Cell mediated response relates to

A

T lymphocytes

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11
Q

Sites of haemopoiesis

A

Bone marrow is primary site

Foetus all bones and liver/spleen

Adult mostly flat bones

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12
Q

Where is the b cell repertoire generates

A

Bone marrow

(Final maturation occurs in the periphery)

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13
Q

Repertoire

A

Range of genetically distinct b and T cell receptors present in a host

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14
Q

Larger repertoire

A

Recognises more threats

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15
Q

Where do T cells mature

A

Thymus (migrate from bone marrow)

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16
Q

Where does T cell selection occur

A

Thymus

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17
Q

Steps of T cell selection

A

Stepwise differentiation:

Positive selection

Negative selection

Final selection and exit

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18
Q

Positive selection in T cell selection

A

Can the T cell receptor signal (identify foreign antigens)

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19
Q

Negative selection of T cell selection

A

Does it react against own body

20
Q

Self

A

Recognised was part of your normal molecular makeup

21
Q

Thymic involution

A

Shrinking of thymus with age

22
Q

How many T cell receptors per T cell

A

1

23
Q

How many litres of blood in the body

A

5

24
Q

How much of total pool of T cells is in the blood

A

2%

25
Q

ul to litre

A

X1000000

26
Q

How does a small population of cells find a foreign protein in a human body

A

Secondary lymphoid tissues

27
Q

Secondary lymphoid tissues

A

Make up secondary lymphoid organs which are where lymphocytes interact with antigens

28
Q

Name some secondary lymphoid organs

A

Tonsils

Lymph nodes

Spleen

Appendix

29
Q

How are lymphoid tissues connected

A

Lymphatic system and blood

30
Q

Lymph nodes have

A

Distinct t and b cell zones

Afferent and efferent lymph

Arterial and venous connection

31
Q

Lymph nodes are

A

Secondary lymphoid tissue/ organs

32
Q

Spleen has

A

Distinct t and b cell zones

Afferent and efferent lymph

Arterial and venous connection

33
Q

Where in the spleen is the lymph tissue

A

Encapsulat3dnwithin red pulp

34
Q

Epithelial barrier is

A

An extensive lymphatic network

The first line of defence against infection

Physical barrier

35
Q

Gut associated lymphoid tissue is found

A

Below epithelium of the ileum of small intestine

36
Q

Secondary lymphoid tissue in the gut

A

Peters patches (below epithelium of small intestine)

37
Q

Where is the largest colony of micobiome

A

Tonsils

38
Q

Waldeyer ring

A

Made up of pharyngeal, tubular, palantine and lingual tonsils

Encircling oral and nasal cavity

39
Q

How do t and b cells and antigens get to secondary lymphoid organs

A

Drainage of fluid from between cells into lymph system and circulation

40
Q

How often to T cells recirculate

A

24 hours

41
Q

How do T cells enter lymph node from blood

A

Extravasion through a high endothelial venue (HEV)

42
Q

Extravasiom of naive T cells

A

Selection binding (rolling and activation)

integrin binding (adhesion and trans endothelial migration)

43
Q

Selectin binding of extravasion t cells

A

Rolling using L selectin and receptor on membrane

Activation when CCR7 binds CCL21 (chemokine)

44
Q

Integrin binding of extravasion of T cell

A

Adhesion when LFA1 binds ICAM1 (mediated by ccr7 during activation)

Transendothelial migration

45
Q

Dendritic cells

A

Antigen presenting to T cell (engulf then migrate to lymph)

Can be migratory or tissue resident

46
Q

DC migration

A

Via afferent lymph into lymph nodes

POM 3 G: IMMUNOLOGY AND INFECTION (10 decks)

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