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MS 2 - Unit 5 > "The Practice of Medicine 2 L29: Dyslipidemia Dx & Tx Kaushal B. Nanavati" > Flashcards

"The Practice of Medicine 2 L29: Dyslipidemia Dx & Tx Kaushal B. Nanavati" Flashcards

1
Q

What is the effect of hypothyroidism on cholesterol?

A

Increase in LDL and triglycerides

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2
Q

What is the effect of type 2 DM on cholesterol?

A

Increase in triglycerides and decrease in HDL

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3
Q

What is the effect of obesity on Cholesterol?

A

Increase in LDL and VLDL and decrease in HDL

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4
Q

What is the effect of smoking on cholesterol?

A

Decrease in HDL

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5
Q

What is the effect of choke static liver disease on cholesterol?

A

Increase in lipoprotein X

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6
Q

What is the effect of nephrotic syndrome on cholesterol?

A

Increase in total cholesterol and LDL

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7
Q

What is the effect of chronic kidney disease on cholesterol?

A

Increase in LDL and triglycerides

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8
Q

What is the effect of weight loss as a treatment for cholesterolemia?

A

Increase in HDL and decrease in LDL when done in a healthy manner

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9
Q

Station medications are similar to what lifestyle modification responsible for lowering cholesterol?

A

The Mediterranean diet

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10
Q

T/F: Smoking cessation shows benefits at reducing cholesterol that far exceed pharmaceutical intervention.

A

True

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11
Q

What is the cardiovascular risk reduction when taking statins?

A

20-30% regardless of baseline LDL

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12
Q

Class: Evolocumab

A

PCSK9 inhibitor

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13
Q

Class: Alirocumab

A

PCSK9 inhibitors

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14
Q

What step so statins inhibit in the cholesterol synthesis pathway?

A

HMG-CoA –> Mevalonate

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15
Q

Garlic has been shown to be as effective at reducing cholesterol as:

A

Bezafibrate

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16
Q

What is he Framingham Eisk Calculator?

A

Calculates risk of having a heart attack or dying from HD within 10 years

Inputs age, systolic BP, total chol, HDL, on HTN meds, cigarette smoker, diabetes present

Screening starts at age 40 in men, 50 in women

17
Q

What is the standard of care for low risk Framingham patients,

A

Retest in 5 years with risk estimation

18
Q

What is the standard of care for Framingham moderate risk patients, 10-19% per year?

A

Discuss initiation of moderate intensity statin

19
Q

What is the standard of care for a Framingham high risk patient,

A

Discuss initiation of a high intensity statin

20
Q

Are statins recommended during pregnancy and breastfeeding?

A

No

21
Q

There is a continuous, positive, relation between plasma cholesterol and what complication?

A

Six year coronary heart risk

MS 2 - Unit 5 (21 decks)

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