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Yale Residency - Rabbits, Guinea Pigs, Misc. Rodents > 11. The Guinea Pig and Hamster in Research > Flashcards

11. The Guinea Pig and Hamster in Research Flashcards

(51 cards)

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1
Q

Guinea pigs are in what suborder?

A

Histricomorphs (Porcupine like) - masseter passes through large infraorbital foramen

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2
Q

Guinea pigs are old or new world rodents?

A

New world

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3
Q

Guinea pigs were the first to b emaintained in axenic state. what does this mean?

A

Free of other microorganisms

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4
Q

Describe length and texture of coats in English, Peruvian, Abyssinian GPs

A

English: Short and straight
Peruvian: Long (whorled or straight)
Abyssinian: Short, rough hair in whorls

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5
Q

Outbred stock of GP

A

Dunkin-Hartley

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6
Q

Inbred strain of GP

A

Strain 2, Strain 13, JY1, JY2, Weiser-Maple

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7
Q

JY1 and JY2 GPs

A

Used for superovulation, embryo transfer, embryo culture

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8
Q

Weiser-Maple strain

A

Radical and vertical growth patterns of melanocytes

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9
Q

Strain 2 and Strain 13

A

multicolored, lower growth rates, less robust

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10
Q

Hartley A

A

Natural resistance to T. pallidum

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11
Q

Complement 4 deficient

A

100% susceptible to T. pallidum - partial autosomal dominant

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12
Q

Waltzing GPs

A

Deafness and circling behavior - Autosomal dominant

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13
Q

German waltzing

A

Inner ear deficiency - deafness, ataxia, circling - recessive
Homozygotes affected, hets have increased resistance to noise induced trauma

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14
Q

Hairless athymic

A

immunodeficient (agammaglobulinemia)

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15
Q

Hairless euthymic

A

Immunocompetent

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16
Q

Life span of GPs

A

2-8yrs

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17
Q

Sexual maturity of GPs

A

60-90days

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18
Q

Estrus cycle length GP

A

16-18 days

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19
Q

Gestation length GP

A

60-65 days

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20
Q

Avg litter size GP

A

2-4

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21
Q

GPs are unable to synthesize Vit C due to lack of what?

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A

L-gulonolactone oxidase

22
Q

Palatal ostium in GPs

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A

Soft palate is contiuous with tongue, causing small hole - palatal ostium

23
Q

Unique cytology

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A

Predominant WBCs
Heterophils
Kurloff cells

24
Q

What are Kurloff cells?

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A

Estradiol-dependent mononuclear leukocyte

Help prevent maternal rejection during pregnancy - form barrier in placenta

25
What is unique about GP distal bronchi?
Most prominent smooth muscle compared to other mammals
26
Which cells are abundant in GP lungs?
Mast cells, eos
27
What's unique about GP pulmonary arteries?
Marked thickening of media | Surrounded by prominent concentric bands of smooth muscle
28
Excess dietary cholesterol leads to what in GPs?
Acute hemolytic anemia
29
What's unique about GP renal arteries?
2-3 pairs supply each kidney
30
GP uterus
Bicornuate, single cervix
31
Why should females be bred <6mos of age?
To prevent dystocia from pelvic symphysis
32
Preyer response
Pinna tilts rearwards with sharp sounds | Used in otologic research
33
Why are GPs used in research?
Long gestation period with mature neuro systm at birth Large TB Nutritional characteristics
34
Buehler test
Compound applied to skin topically 3x followed by challenge
35
GPs are used to study which herpesvirus?
HSV2 (simplex)
36
Sereny test
Assay for bacterial invasiveness - organisms placed in conjunctival sac, leading to development of keratoconjunctivitis
37
Suborder of hamsters
Myomorpha
38
Syrian/golden hamster g/s
Mesocricetus auratus
39
Chinese/grey hamster g/s
Cricetulus griseus
40
European/black-belled hamster g/s
Cricetus cricetus
41
Armenia/migratory hamster g/s
Cricetulus migratorius
42
Djungarian, Siberian, Dwarf, striped hairy footed hamster g/s
Phodopus sungorus
43
Lifespan of hamsters
1.2-2 years
44
Avg litter size of hamsters
5-10
45
Gestation period for hamsteres
15-16 days
46
How are hamster cheek pouches unique?
Lack lymphatic drainage pathways - immunologically privileged
47
Flank glands of hamsters develop neoplasia when what happens?
With simultaneous stimulation by androgens and estrogens
48
Which strain of hamster is used for cardiomyopathy?
Strain BIO 14.6
49
Hamsters were the first animal model for Cushing's or Addison's?
Addison's
50
Application of what to hamster cheek pouches causes SCC?
DMBA
51
Hamster cheek pouches are ideal for what kind of graft?
Xenograft without rejection

Yale Residency - Rabbits, Guinea Pigs, Misc. Rodents (18 decks)

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