Neuro - Altered Conscious Level and Neurological Disturbance Flashcards

(46 cards)

1
Q

Loss of consciousness spectrum and summary of causes

A

Spectrum:
Syncope/Blackout
Impaired conscious level
Coma

Causes: BBBMF
Brain
Beat (Heart)
Blood
Metabolic
"Failure" (organ)
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2
Q

Loss of Consciousness - Brain

Presentation and DDx

A

Neurological - Impaired conscious level/coma

Diffuse intracranial:
SAH, Epilepsy, Meningitis, Encephalitis

Hemisphere lesion [Cerebral]:
Subdural, Extradural, Stroke/TIA

Brain stem [Brainstem/Cerebellar]:
Any of the above - Raised ICP pushes on brain stem

Peripheral Nervous system:
Peripheral (Autonomic) Neuropathy

Hyponatraemia
Hypocalcaemia

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3
Q

“SHIT”

A

abscesS
Haemorrhage
Ischaemia/Infarct
Tumour (primary/secondary)

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4
Q

Loss of Consciousness - Beat

Presentation and BP formula

A

Cardiac –> Blackouts
Syncope - Loss in consciousness due to a sudden drop in blood pressure

BP=HRxSVxTPR

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5
Q

Components of BP formula

A

HR: Bradycardia + Arrhythmias

SV (inc. Outflow obstruction):
Tamponade, Cardiomyopathy
Left: HOCM/Aortic stenosis
Right: PE

TPR (inc. Neuropathy):
Vagal overactivity
Peripheral (autonomic) neuropathy

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6
Q

Loss of Consciousness - Blood

Presentation

A

Blood/Vasculature –> Impaired consciousness/Blackout

Venous - Pooling
Arterial - Atherosclerosis e.g. Vertebrobasilar insufficiency (TIA, CVA), shock
Anaemia

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7
Q

Metabolic causes of impaired conscious level/coma

A
Hypoglycaemia/Hyperglycaemia
Hyper/Hypocalcaemia
Hyper/Hyponatraemia
Drug overdose/poisoning/toxins
Addisonian Crisis, Myxoedema
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8
Q

Organ failure causes of impaired conscious level/coma

A

Hepatic encephalopathy
Uraemic Encephalopathy
Hypoxia/CO2/Narcosis (COPD)

–>Liver/Kidneys/Lungs

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9
Q

Blackout - COLLAPSED

A
Carotid Sinus Syncope
Orthostatic (Postural) Hypotension
refLex - Vasovagal (Neurocardiogenic) Syncope
Low Glucose (Diabetics)
Arrhythmia/Stroke's Adam's Attack
Panic (--> Anxiety --> Hyperventilation)
Situational Syncope
Epilepsy
Drop Attacks
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10
Q

Brain Haemorrhages

A

Extradural: Classic ‘lucid interval’ before LOC = arterial bleed

Subdural: Hx of falls, progressive confusion = venous bleed between dura and arachnoid layers

Subarachnoid: sudden severe headache = bleeding into the subarachnoid space. Half of all patients lose consciousness and altered mental status is common.

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11
Q

Brain - Raised ICP

A

Raised ICP –> Space occupying lesion –> Abscess/Haemorrhage/Infarction/Tumours (SHIT); Oedema; Head injury

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12
Q

Raised ICP compressive signs

A
Headache
Nausea and Vomiting
Altered GCS
Papiloedema
Focal neurology
Pupil changes - dilatation; down and out.
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13
Q

Raised ICP herniation

A

CN III (opthalmoplegia)
Ataxia
Apnoea

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14
Q

Transient Loss of Consciousness

A

Either increased vagal or decreased sympathetic activity

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15
Q

Carotid Sinus Syncope

A

Hypersensitive Baroreceptors –> Excessive reflex bradycardia +/- vasodilation on minimal stimulation, e.g. head turning/shaving

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16
Q

refLex - vasovagal (neurocardiogenic syncope)

A

Reflex Bradycardia +/- vasodilation provoked by emotion/pain/fear/standing too long

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17
Q

Transient Arrhythmias (Stroke’s Adam’s attack)

A

–> Decrease in Cardiac Output –> LOC.

Collapses with no warning, pale, slow/absent pulse; Recovery in seconds, patient flushes, pulse recovers

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18
Q

Situational Syncope

A

Cough, Effort (e.g. exercise; cardiac origin), Micturition (mostly men)

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19
Q

Postural Hypotension

Definition, Presentation, Diagnosis

A

Drop in systolic BP > 20 mmHg or diastolic BP > 10 mmHg after standing for 3 mins vs lying

Elderly
Hypovolaemia
Drugs (Nitrates, Diuretics, Antihypertensives, Antipsychotics)
Peripheral Neuropathy –> Inadequate Vasomotor reflex (insufficient sympathetic increase in HR/vasoconstrution) = DM, Parkinson’s disease, MSA, Autonomic Neuropathy
Endocrine = Addison’s, Hypopituitarism (decreased ACTH)

Good history and Lying/Standing BP should be enough to diagnose. Confirm with Tilt test

20
Q

Aortic Stenosis

Definition, Presentation, Clinical signs

A

Narrowed valve orifice
20% due to congenital bicuspid valve
Most common cause in adults is calcification of normal trileaflet valves

Presents with…
Dyspnoea
Chest Pain
Syncope

Clinical signs…
Harsh ejection systolic murmur heard loudest at the right upper sternal edge at end expiration, which radiates up towards the carotids.
Narrow pulse pressure
Slow rising pulse

21
Q

Hypoglycaemia presentation

A

Symptoms present when glucose <3mmol/L:
Mainly Diabetic on NEW insulin/Oral hypoglycaemic + exercise
Alcohol, Liver Failure = risk factor –> Decreased hepatic glucose production.

Symptoms;
Sweating
Weakness
Decreased GCS: Drowsiness --> LOC
Palpitations and anxiety
22
Q

Blackout Investigations

A

Depends on suspected cause

Bedside: Examination - Cardio, Neuro, Lying/Standing BP
Fluids: FBC, UandE, Glucose, ABG
Imaging:
ECG/Cardiac Monitor/24 hr tape
Echocardiogram
EEG, CT/MRI
23
Q

GCS Summary

A

Glasgow Coma Scal eis the most commonly used scoring system for initial assessment and monitoring of a patient’s level of consciousness.

Assessment of…
Eye opening (4)
Best Verbal Response (5)
Best Motor response (6)

24
Q

AVPU

A

Primary survey

Alert
responds to Vocal stimuli
responds to Pain
Unresponsive

25
GCS Detailed
``` Motor 1-6: No response to pain Extensor response to pain Flexor response to pain Withdrawing to pain Localising to pain Obeying commands ``` ``` Verbal 1-5: None Incomprehensive sounds Inappropriate speech Confused (disoriented) Oriented (time/place/person) ``` ``` Eyes 1-4: None In response to pain In response to voice Spontaneous ```
26
GCS score ranges and implications
3: Globally no response 8 or less: Coma, Severe injury, Consider airway 9-12: Moderate injury 13-15: Minor injury
27
Stroke Definition
Rapidly developing clinical signs of focal or global disturbance of cerebral function, with symptoms lasting 24 hrs or more, with no apparent cause other than that of a vascular origin.
28
TIA Definition
Transient ischaemic attacks are acute episodes of focal loss of cerebral function lasting less than 24 hrs, which are attributed to an inadequate blood supply.
29
UMN lesion clinical features
``` Contralateral Signs – motor and sensory NO fasciculations NO muscle wasting Spasticity Weakness – Extensors-Arms; Flexors-Legs Hyperreflexia Upgoing Plantar response Pronator Drift ```
30
Anterior Cerebral Artery | anatomy and pathophysiology
Frontal and parietal lobes Disturbance of judgement Loss of social behaviour Contralateral hemiparesis leg > arm Mild sensory deficit
31
Middle Cerebral Artery | anatomy and pathophysiology
Frontal, Parietal, Temporal Lobe, Subcortical Structures (e.g. Basal Ganglia) Internal Capsule Contralateral hemiplegia arm/face/thorax > leg Aphasia (Broca & Wernicke’s areas) Hemisensory deficits
32
Posterior Cerebral Artery | anatomy and pathophysiology
Occipital and Lower Temporal Lobe Visual Defects: Homonymou hemianopia Visual agnosia Prosopagnosia
33
TIA Clinical Features
(Common in SBAs is a description of) Focal neurological deficit unilaterally, e.g. Amaurosis Fugax (Transient and painless loss of vision in one eye due to the passage of an embolus into the central retinal artery).
34
TIA Ix/Rx
CT Head to exclude a haemorrhagic aetiology immediately. - -> Depressed consciousness (GCS < 13) - -> Suspected haemorrhage (drugs etc) or Raised ICP Consider thrombolysis with tPA if within the 4.5 hour window and there are no contraindications. --> Thrombolysis is done with Alteplase (tPA) at 10% bolus, 90% infusion at a dose of 0.9mg/kg Presentation after the 4.5 hr window is managed with aspirin. All people presenting with acute ischaemic stroke should be given aspirin.
35
Seizures/Epilepsy | Definition and Pathophysiology
Seizure - A paradoxical discharge of cerebral neurons --> External manifestations Epilepsy - A recurring tendency to have seizures. Before: epileptic aura (marks onset), triggers (flashing lights) During: stiffness, jerking, incontinence, side tongue-biting, sweating, palpitations, mouth frothing, pallor, cyanosis After: muscle ache, post-ictal confusion/drowsiness Seizures may be partial (focal) or generalised (involving both hemispheres)
36
Partial seizures | Categorization and complications
Simple Partial [Focal motor/sensory/autonomic/psychic] Awareness unimpaired No post-ictal confusion Complex Partial [Deja-vu, depersonalisation, altered emotion, epigastric fullness; can start as simple partial (=aura)] Most commonly arise form the temporal lobe Awareness/consciousness is impaired Post-ictal confusion common
37
Partial seizures Localising Features | Frontal lobe
``` Behaviour Motor – posturing, peddling Dysphasia/speech arrest Motor arrest, subtle behaviour disturbances Jacksonian March ```
38
Partial seizures Localising Features | Temporal Lobe
``` Complex Emotional disturbance Hallucinates (smell/taste) Depersonalisation Automatisms ```
39
Partial seizures Localising Features | Parietal Lobe
Sensory disturbance – tingling, numbness | Motor symptoms – abnormal movement/rhythmic muscle contractions
40
Partial seizures Localising Features | Occipital Lobe
Visual phenomena - spots, lines, flashes
41
Primary Generalised Seizures | Pathophysiology
Convulsive vs Non-Convulsive Convulsive: Tonic - limb stiffening Clonic - limb jerking Tonic-Clonic - LOC followed by a stiff body with flexed elbows and extended legs followed by violent shaking with eyes rolling (grand mal), incontinence, post-ictal and drowsiness Myoclonic - sudden isolated jerk of limb, face or trunk; disobedient limb --> thrown to the ground Non-Convulsive: Absence - 10s or fewer of vacancy, sometimes myoclonic jerks (petit mal), presents in childhood - no post ictal. Atonic (Akinetic) - Sudden loss of muscle tone, 'Drop Attacks'. No LOC
42
Status Epilepticus | Definition and Rx
Continuous seizure or serial (at least 2) discrete seizures between which there is incomplete recovery of consciousness of at least 30 min duration. --> Medical Emergency Rx: ABC - open and maintain airway, recovery position Oxygen 100% Stop seizures --> Slow IV Bolus Lorazepam (1) 204mg --> Lorazepam (2) if no response in 10 mins Continuing seizures --> IV Phenytoin/Diazepam
43
Encephalitis | Definition, Causes, Signs, Ix
Brain parenchyma inflammation - may be focal symptoms Causes Viral - HSV, CMV, EBV, VZV Non-viral - Any bacterial meningitis, TB, cryptocossus, etc Bizarre Encephalopathic behaviour Decreased GCS/Coma Focal signs Seizures CT - cerebral oedema - compressive symptoms (Medical Emergency
44
Meningitis
Meningeal Inflammation Causes: Meningococcus Pneumococcus ``` Headache Meningism Decreased GCS/Coma Focal signs Seizures Fever Rash Kernig's sign + Brudzinski + ```
45
Encephalitis vs Meningitis
Encephalitis: Compressive symptoms/focal YES Seizures YES Altered Mental State YES Meningitis: Meningism YES Seizures < encephalitis Altered mental state < encephalitis
46
Metabolic LOC/Seizures | Presentations and Causes
Hyponatraemia (<135) Headaches, comiting, drowsiness, seizures Thiazide Diuretics (Hypo/Eu/Hypervolaemic) Hypocalcaemia e.g. complicatoin of thyroid surgery (loss of parathyroids) 4 CATS - Consulvsions, Arrhythmia, Tetany, Spasms Chvostek's and Trousseau's signs (Face and hand)