Neuro - Altered Conscious Level and Neurological Disturbance Flashcards
(46 cards)
Loss of consciousness spectrum and summary of causes
Spectrum:
Syncope/Blackout
Impaired conscious level
Coma
Causes: BBBMF Brain Beat (Heart) Blood Metabolic "Failure" (organ)
Loss of Consciousness - Brain
Presentation and DDx
Neurological - Impaired conscious level/coma
Diffuse intracranial:
SAH, Epilepsy, Meningitis, Encephalitis
Hemisphere lesion [Cerebral]:
Subdural, Extradural, Stroke/TIA
Brain stem [Brainstem/Cerebellar]:
Any of the above - Raised ICP pushes on brain stem
Peripheral Nervous system:
Peripheral (Autonomic) Neuropathy
Hyponatraemia
Hypocalcaemia
“SHIT”
abscesS
Haemorrhage
Ischaemia/Infarct
Tumour (primary/secondary)
Loss of Consciousness - Beat
Presentation and BP formula
Cardiac –> Blackouts
Syncope - Loss in consciousness due to a sudden drop in blood pressure
BP=HRxSVxTPR
Components of BP formula
HR: Bradycardia + Arrhythmias
SV (inc. Outflow obstruction):
Tamponade, Cardiomyopathy
Left: HOCM/Aortic stenosis
Right: PE
TPR (inc. Neuropathy):
Vagal overactivity
Peripheral (autonomic) neuropathy
Loss of Consciousness - Blood
Presentation
Blood/Vasculature –> Impaired consciousness/Blackout
Venous - Pooling
Arterial - Atherosclerosis e.g. Vertebrobasilar insufficiency (TIA, CVA), shock
Anaemia
Metabolic causes of impaired conscious level/coma
Hypoglycaemia/Hyperglycaemia Hyper/Hypocalcaemia Hyper/Hyponatraemia Drug overdose/poisoning/toxins Addisonian Crisis, Myxoedema
Organ failure causes of impaired conscious level/coma
Hepatic encephalopathy
Uraemic Encephalopathy
Hypoxia/CO2/Narcosis (COPD)
–>Liver/Kidneys/Lungs
Blackout - COLLAPSED
Carotid Sinus Syncope Orthostatic (Postural) Hypotension refLex - Vasovagal (Neurocardiogenic) Syncope Low Glucose (Diabetics) Arrhythmia/Stroke's Adam's Attack Panic (--> Anxiety --> Hyperventilation) Situational Syncope Epilepsy Drop Attacks
Brain Haemorrhages
Extradural: Classic ‘lucid interval’ before LOC = arterial bleed
Subdural: Hx of falls, progressive confusion = venous bleed between dura and arachnoid layers
Subarachnoid: sudden severe headache = bleeding into the subarachnoid space. Half of all patients lose consciousness and altered mental status is common.
Brain - Raised ICP
Raised ICP –> Space occupying lesion –> Abscess/Haemorrhage/Infarction/Tumours (SHIT); Oedema; Head injury
Raised ICP compressive signs
Headache Nausea and Vomiting Altered GCS Papiloedema Focal neurology Pupil changes - dilatation; down and out.
Raised ICP herniation
CN III (opthalmoplegia)
Ataxia
Apnoea
Transient Loss of Consciousness
Either increased vagal or decreased sympathetic activity
Carotid Sinus Syncope
Hypersensitive Baroreceptors –> Excessive reflex bradycardia +/- vasodilation on minimal stimulation, e.g. head turning/shaving
refLex - vasovagal (neurocardiogenic syncope)
Reflex Bradycardia +/- vasodilation provoked by emotion/pain/fear/standing too long
Transient Arrhythmias (Stroke’s Adam’s attack)
–> Decrease in Cardiac Output –> LOC.
Collapses with no warning, pale, slow/absent pulse; Recovery in seconds, patient flushes, pulse recovers
Situational Syncope
Cough, Effort (e.g. exercise; cardiac origin), Micturition (mostly men)
Postural Hypotension
Definition, Presentation, Diagnosis
Drop in systolic BP > 20 mmHg or diastolic BP > 10 mmHg after standing for 3 mins vs lying
Elderly
Hypovolaemia
Drugs (Nitrates, Diuretics, Antihypertensives, Antipsychotics)
Peripheral Neuropathy –> Inadequate Vasomotor reflex (insufficient sympathetic increase in HR/vasoconstrution) = DM, Parkinson’s disease, MSA, Autonomic Neuropathy
Endocrine = Addison’s, Hypopituitarism (decreased ACTH)
Good history and Lying/Standing BP should be enough to diagnose. Confirm with Tilt test
Aortic Stenosis
Definition, Presentation, Clinical signs
Narrowed valve orifice
20% due to congenital bicuspid valve
Most common cause in adults is calcification of normal trileaflet valves
Presents with…
Dyspnoea
Chest Pain
Syncope
Clinical signs…
Harsh ejection systolic murmur heard loudest at the right upper sternal edge at end expiration, which radiates up towards the carotids.
Narrow pulse pressure
Slow rising pulse
Hypoglycaemia presentation
Symptoms present when glucose <3mmol/L:
Mainly Diabetic on NEW insulin/Oral hypoglycaemic + exercise
Alcohol, Liver Failure = risk factor –> Decreased hepatic glucose production.
Symptoms; Sweating Weakness Decreased GCS: Drowsiness --> LOC Palpitations and anxiety
Blackout Investigations
Depends on suspected cause
Bedside: Examination - Cardio, Neuro, Lying/Standing BP Fluids: FBC, UandE, Glucose, ABG Imaging: ECG/Cardiac Monitor/24 hr tape Echocardiogram EEG, CT/MRI
GCS Summary
Glasgow Coma Scal eis the most commonly used scoring system for initial assessment and monitoring of a patient’s level of consciousness.
Assessment of…
Eye opening (4)
Best Verbal Response (5)
Best Motor response (6)
AVPU
Primary survey
Alert
responds to Vocal stimuli
responds to Pain
Unresponsive