PPI

Question 1

name a PPI

Answer 1

omeprazole

Question 2

what is it used for?

Answer 2

[1] first line treatment of Peptic ulcer for prevention and treatment, often given with long term NSAID use
[2] second line treatment for dyspepsia, GORD esp more severe cases
[3] h.pylori eradication therapy- treatment of H.pylori alongside antibiotics (2x)

Question 3

MOA:

Answer 3

supresses gastric acid production almost completely by inhibiting the K+ H+ ATPase in parietal cells

Question 4

side effects

Answer 4

GI disturbances
headache
increase c.difficile risk

hypomagnesia

Question 5

what can hypomagnesia cause

Answer 5

tetany and ventricular arrhythmia

Question 6

what is the problem with this medication

Answer 6

can disguise symptoms of gastric cancer

Question 7

risk with prolonged treatment

Answer 7

increases risk of fractures

and monitor magnesium

Question 8

drug interactions

Answer 8

can reduce anti platelet effect of clopidogrel by decreasing P450 enzymes

Question 9

alternative for clopidogrel patients

Answer 9

lansoprazole and pantoprazole

Question 10

best taken when

Answer 10

in morning, on empty stomach or with food

Question 11

formulations

Answer 11

oral or injectable

Question 12

how long is course In h.pylori

and GORD

Answer 12

7 days

4 weeks max before review - if not successful consider surgery

Question 13

other drug interactions

Answer 13

decreases clearance of methotrexate so avoid.

increase exposure to citalopram
decrease exposure to atazanvir