7 Flashcards
product rule
probability of independent events occurring together in the product of the probabilities of the individual events
sum rule
probability of either of two mutually exclusive events occurring is the sum of their individual properties
pleiotropy
one gene can affect multiple traits
Difference between Mendel and other plant hybridisers
M studied true-breeding strains unlike others who used complex and poorly defined material
M focused on one trait or small number of traits with characteristics that were easily contrasted among the true-breeding strains
M counted the progeny of his crosses, looking for statistical patterns in the offspring of his crosses
Incomplete dominance
phenotype of the heterozygous genotype is intermediate between those of the homozygous genotypes
features of pedigree that suggest dominant inheritance
Affected individuals are equally likely to be females or males
Most mating that produce affected offspring have only one affected parent because mating between two affected individuals is extremely unlikely
Among matings in which one parent is affected, approximately half the offspring are affected
recessive inheritance
Trait may skip one or more generations
Both genders equally likely to be affected
Affected individuals mat have unaffected parents
Affected individuals often result form mating between relatives, typically first cousins
GINA
forbids use of genetic information in decisions concerning employment and health insurance
DTC tests
can be purchased without professional where consumer sends biological samples but may not be reliable or accurate
X-linked recessive inheritance
Affected individuals are usually males because males need only one copy of the mutant gene to be affected, whereas females need two copies to be affected
Affected males have unaffected sons because males transmit their X chromosome only to their daughters
A female whose father is affected can have affected sons because such a female must be a heterozygous carrier of the recessive mutant allele
Sisters of an affected male each have a 50% change of being a heterozygous carrier because when a brother is affected the mother must be heterozygous for the recessive allele