Parkinson's drugs Flashcards
4 classes of drugs used in parkinson’s and examples of them
Levodopa - sinemet, madopar
dopamine agonist - ropinirole, rotigotine
MAO-B inhibitor - seligiline
COMT inhibitor - Entacapone
when are acetylcholine inhibitors used in parkinson’s disease?
only in young patients who suffer from bad tremors
what other drug must be given with Ldopa? why?
dopa-decarboxylase inhibitor (DDI)
prevent peripheral action of Ldopa
what are some side effects of Ldopa
short term -
N&V, anorexia
postural hypotension
psychiatric disturbance
sleep disorders
long term -
dyskinesia
response fluctuation
psychiatric effects
how to manage long term response fluctuation to Ldopa?
fractionate dosing
addition of adjuvants
preperations available for dopamine agonist?
oral, transdermal or subcut
side effects of dopamine agonists?
postural hypotension, N&V, confusion, impulse control disorder
what must patients be warned of before starting dopamine agonists
impulse control disorders
what interactions can MOAB inhibitors cause with SSRIs
serotonin syndrome
side effects of maob inhibitors
nausa and vomiting
confusion
what side effects do comt inhibitors have
N&V confusion
diarrhea
bodily fluids discoloration
dyskinesia
what is the first line drug of choice for PD patients in young and in old?
old - Ldopa+
young - MOAB inhibtor, or DA agonist
what is the treatment of last resort if drug treatments don’t work?
deep brain stimulation
how to treat dyskinesia secondary to PD drugs?
reduce Ldopa dose, add amantadine
what is amantadine used for in PD patients?
treats dyskinesia
