HL Flashcards

1
Q

Cell type a/w HL

A

Reed Sternberg

Arises from post-germinal B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

MC type of “classical”

A

Nodular sclerosis (70%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

B symptoms in what % of patients

A

20-50%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Describe Ann Arbor staging

A
o I – single LN region.
o II – 2 or more regions on same side of
diaphragm.
o III – LN regions on both sides of
diaphragm.
o IV – noncontiguous
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Treatment (firstline)

A

Early stage: ABVD (doxorubicin, bleomycin,
vinblastine, dacarbazine) for 2-4 cycles +
XRT OR 4-6 cycles alone.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Prognosis (%)

A

Early stage: Cure rate 85-90%.

Advanced stage: Cure rate ~75%.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Unfavorable factors

A
  • Stage I/II if age >50,
  • ESR >50
  • B-symptoms+ESR >30
  • Extranodal disease, or large mediastinal LAD
  • > 2 nodal sites of involvement
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Complications for women

A

Breast Ca if received XRT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Is F&N common?

A

No, <1%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Is BMBx routine?

A

No, only if question of diffuse disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Adriamycin AE are primarily

A

cardiac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Bleomycine AE are primary

A

lung, increased risk of PJP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

XRT SE

A

thyroid failure, radiation fibrosis syndrome (head drop)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Treatment (salvage)

A

RICE:

  • Rituxan D1
  • Ifosfamide IVB D1-3 with Mesna D2-4 prior to ifosfamide and 3 & 6 hours after
  • Carboplatin IVB D2
  • Etoposide D1-3

*Neulasta 24-48h following last dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Isofosfamide primary AE, and what to do to prevent

A

Hemorrhage cystitis

  • UOP >150cc/hr
  • Mesna before and after
  • Daily Cr monitoring
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Rituxan often administered with what non-chemo med

A

Hypersensitivity pre-meds (often Benadryl/Tylenol/Hydrocort)

17
Q

RICE is highly emetogenic. What anti-nausea meds are typical?

A

Zofran 16 mg IV daily, Emend+Dex w/ Ativan prn, +/- compazine

18
Q
RICE AE
(Hint: HAOOM is acronym)
A
Hemorrhagic cystititis
AMS (neurotoxicity)
Alopecia
Otoxicity
Mucositits
19
Q

HL and NHL are not “high risk” lymphoma. What are high risk forms ?

A

DLBCL, Burkitt’s