Substance Use Disorder

Question 1

What n/t are enhanced in alcohol use disorder?

Answer 1

5HT3

GABA-A

Question 2

What n/t are inhibited in alcohol use disorder?

Answer 2

Glutumate

Voltage gated calcium

Question 3

What are risk factors for developing alcohol use disorder?

Answer 3

Children of alcoholics
Deficits on neurocognitive testing
Low amplitude p300 waves on EEG
ADHD
Conduct disorder

Question 4

In alcohol use disorder, what are the positive hedonic effects?

Answer 4

Increased dopamine
increased opioid peptides
increased serotonin
increased GABA

Question 5

How do you treat co-morbidity in AUD?

Answer 5

Integrated
Parallel
Sequential

Question 6

Treatment modalities for opioid use disorder?

Answer 6

Psychodynamic therapy
CBT
Motivational enhancement therapy
12 step facilitation 
Contingency management
Group therapy
Network therapy
Family therapy 
MI

Question 7

SUD, DSM Criterion ?

Answer 7

MILD - 2-3 criteria
MODERATE 4-6 criteria
SEVERE 7 - 11

Question 8

What are DSM domains in SUD ?

Answer 8

1. IMPAIRED CONTROL
   - larger amounts than was intended
   - persistent desire and unsuccessful effort to cut down or control use
   - lots of time spent to obtain and recover from substance
   - craving, or strong urge to use
2. Social Impairment
   - recurrent failure to fulfill obligations at work, school, or home.
   - continued use despite persistent or recurrent social or interpersonal problems exacerbated by substance.
   - Important social, occupational, or recreational activities are given up.
3. Risky Use
   - recurrent use in situations which are physically hazardous
4. Pharmacological Criterion:
   Tolerance - need more to achieve same effect or diminished effect
   Withdrawal - syndrome or substance taken to avoid withdrawal

Question 9

What is SBRIT ?

Answer 9

1. Screening
2. Brief Intervention
3. Referral to treatment