9.hydrogen sulfide

Question 1

etiology of hydrogen sulfide intoxication

Answer 1

1.in oil and gas extraction industries
2.in wastewater treatment
3.rubber and mining industries

Question 2

pathogenesis of hydrogen sulfide poisoning

Answer 2

1.exposure through inhalation
2.it is highly soluble in water and readily absorbed through respiratory tract
3.rapid distribution through body and can cross BBB
-neurotoxic effects
4.inhibits mitochondiral cytochrome oxidase
-impaired cellular respiration, aerobic metabolism
5.generates ROS

Question 3

clinical manifestation of hydrogen sulfide poisoning

Answer 3

1.cough, dyspnea, nausea, vomiting
2.hypotension, bradycardia - shock
3.headache, dizziness
4.cyanosis,asphyxia

Question 4

diagnosis of hydrogen sulfide poisoning

Answer 4

1.clinical evaluation
-exposure history, nature and duration
-onset and progression of symptoms
2.ABG - hypoxemia, metabolic acidosis
3.CBC - hemolysis, leucocytosis
4.CXR - to assess for pulmonary edema
5.ECG - to evaluate cardiac aarhytmias

Question 5

treatment of hydrogen sulfide poisoning

Answer 5

1.immediate removal from exposure
2.high flow O2 therapy in respiratory distress
3.i.v fluids and vasopressor medications for hypotension
4.decontamination with water and saline solution
5.bronchodilators/constrictors
6.anticonvulsants for seizures

Question 6

medical expertise of hydrogen sulfide poisoning

Answer 6

1.promote awareness of hazards associated with hydrogen sulfide
2.advocate for implementation of effective control measures
3.education about importance of personal protective equipment, safe work practices