Abs/B Cells Flashcards
1
Q
Disulfide Bonds in Igs
A
Hold HCs together, hold LCs to HCs, and within LCs and HCs
2
Q
4 Cs of Fc Region
A
Constant
Carboxy terminal
Complement binding
Carbohydrate side chains
3
Q
Antibody Diversity Mech
A
Have VJ (LC) or VDJ (HC) which join in random combinations and undergo somatic hypermutation following Ag stimulation. dsDNA breaks at Recombination Signal Sequences (RSSs) that flank V, D, and J coding regions, initiated by RAG1 and 2. Mutations cause arrest of B and T cell development
4
Q
Normal Kappa:Lambda LC Ratio
A
2:1
5
Q
Primary vs. Secondary Abs
A
IgM is primary (immediate, acute infection)
IgG is secondary (delayed)
6
Q
Ab that Crosses Placenta
A
IgG. But 21 day half life so baby can be susceptible 1-3 months
7
Q
Ab in Secretions (like breast milk)
A
IgA
8
Q
2 Complement Fixing Abs
A
IgG and IgM (but IgM doesn’t cross placenta)
9
Q
2 Abs on B Cell Surface
A
IgM (monomer on surface though) and IgD
