Adrenal Glands

Question 1

This is the most common histologic change in the pituitary wherein the normal granular, basophilic cytoplasm of acth- producing cells becomes homogenous and paler due to high glucocorticoids.

Answer 1

Crooke hyaline change

Question 2

With exogenous glucocorticoids, the adrenal undergoes atrophy. Which layer of the adrenal cortex remains of normal thickness?

Answer 2

Zona glomerulosa

Remarks: because this layer functions independent of ACTH.

Question 3

What is the most common cause of primary hyperaldosteronism?

Answer 3

Bilateral nodular hyperplasia of the adrenal glands (idiopathic hyperaldosteronism)

Question 4

True or false. Hyperaldosteronism causes adrenal atrophy?

Answer 4

False

Remarks: hyperaldosteronism, unlike in cushing syndrome, does not produce adrenal atrophy.

Question 5

Adrenocortical neoplasms with virilization is more likely to have benign or malignant lesions?

Answer 5

Malignant lesions commonly adrogen-secreting adrenal carcinomas

Question 6

21 hydroxylase deficiency is associated with what gene mutation?

Answer 6

CYP21A2 mutation

Question 7

What is the most common site of gastinoma in patients with MEN1?

Answer 7

Duodenum