Adverse Drug Reactions

Question 1

Separating beneficial(therapeutic) effects from toxic(adverse) effects

Answer 1

Clinical selectivity

Question 2

Diminished responsiveness to a drug’s effects shortly after it is started (acute)
-Rapid Desensitization

Answer 2

Tachyphylazxis

Question 3

Decreased responsiveness to a drug’s effects as a consequence of prolonged drug administration
-Gradual Desensitization

Answer 3

Tolerance

Question 4

Hyperreactivity that is mediated by immunologic mechanisms

Answer 4

Hypersensitivity

Question 5

That the unwanted effect in question is insignificant or occurs via a pathway that is to one side of the principal action of the drug; such implications are frequently erroneous

Answer 5

Side effect

Question 6

The concentration range of drug that provides therapeutic efficacy with minimal toxicity

Answer 6

Therapeutic Window

Question 7

How selective the drug is in producing its desired effects versus its adverse effects

Answer 7

Therapeutic Index (TI)

Question 8

The study of genetic factors determining the response to drugs

Answer 8

Pharmacogenomics

Question 9

Drug reactions that occur rarely and unpredictably amongst the population

Answer 9

Idiosyncratic response

Question 10

The intensity of a drug’s effects is diminished or increased compared with the effect seen in most individuals

Answer 10

Hypo- or Hyperreactivity