Alcohols Flashcards Preview

P Pha T > Alcohols > Flashcards

Flashcards in Alcohols Deck (7):
1

Alcohol dehydrogenase
- _______-order kinetics

zero

2

Chronic ethanol consumption induces P450 enzyme synthesis and MEOS( microsomal ethanol oxidizing system) activity... development of tolerance to alcohol.
Acetaldehyde is rapidly metabolized to _________ by aldehyde dehydrogenase, which is inhibited by:
disulfiram, metronidazole, oral hypoglycemics, and some cephalosporins.
Genetic variant of aldehyde dehydrogenase in Asians: ALD 1.1 (works ten times slower)

acetate

3

Blood alcohol conc (mg/dL) considered legally drunk in the Philippines
BAC corresponding to respiratory depression, death

60
500

4

Most common complication of chronic alcohol abuse

Liver disease

5

Most common neurologic abnormality in chronic alcoholics

Peripheral neuropathy

6

Wernicke's-Korsakoff syndrome
Triad?
What changes in the brain are seen?
Vitamin to be administered?

Ataxia, confusion, ophthalmoplegia (Think: Weird ACO)
Hemorrhagic necrosis of mammillary bodies
B1

7

Heavy alcohol use predisposed one to infectious pneumonia, especially the one caused by ___________

Klebsiella

Decks in P Pha T Class (62):