all refs Flashcards
O’Reilly and Olaya-Castro, 2014
Proved that LHCs display quantum features with no counterpart in classical physics which they efficiently exploit for energy transport
Rintamäki et al., 1997
Maximal phosphorylation of LHCII polypeptides only occurred at low light intensities and drastically decreased at higher irradiance
They demonstrated this using an immunological approach, using anti-pT antibodies
Lindert, Cramer, Meuli et al. 2009
MTF-1 has NLS in its DNA binding motif (zinc fingers), which confers constitutive nuclear localisation
Deleting zinc fingers –> no nuclear localisation
Meynard et al., 2011
TMPRSS6 expression induced by EPO, hypoxia, acute iron deprivation at protein level
They demonstrated that TMPRSS6 levels are also regulated by iron and BMP6 –> important physiological inducers (activators) of hepcidin expression
This exerts some negative feedback to make sure hepcidin is not overexpressed, to maintain homeostatic balance
Liu, Davidoff, Niss et al., 2012
Showed that HIF-mediated suppression of the hepcidin gene requires EPO induction
EPO –> associated with increased erythropoietic activity
Tobuchi et al., 2002
DMT1 splice variants (isoforms) exhibit a differential cell-type specific expression pattern and sub cellular localisation
DMT1A –> 3’ IRE, epithelial cell lines
DMT1B –> no IRE, blood cell lines
Zhang et al., 2009
Duodenal enterocytes and erythroid precursors cells use an alternative upstream promoter to express a ferroportin transcript with no 5’UTR –> not repressed in iron-deficient conditions
This allows to bypass the IRP/dependent repression in intestinal iron take + in erythroid precursors cells it enhances sensing of iron status and facilitates restriction of erythropoiesis in response to low systemic iron
Nakagawa et al., 2014
The sweet taste receptor TIR3 may mediate some of the effects of glucose on pancreatic B-cells, by further enhancing the metabolism of the sugar
Niemeyer et al., 1975
HkIV has a very high Km (around 10mM) and cooperative (Hill coefficient approx. 1.5)
Larion and Miller, 2012
Proposed the mnemonical model for cooperative binding in Glucokinase, according to which glucose acts as a homotropic effector over time:
Its steady state velocity go G6P production displays a sigmoidal response to increasing glucose concentrations
Hofmeister-Brix et al., 2013
GRP not expressed in pancreas. instead, GCK regulation is predominantly mediated by ubiquitination and interaction with proteins having ubiquitin-like domains
