Aminoglycosides

Question 1

aminoglycosides

Answer 1

group of powerful antibiotics used to treat serious infection caused by gram negative aerobic bacilli.

Question 2

Aminoglycoside examples

Answer 2

gentamicin

tobramycin

Question 3

Therapeutic actions and indications of aminoglycosides

Answer 3

bactericidal-inhibit protein synthesis in gram negative bacteria. used for infections such as: pseudomonas, e. coli, proteus, klebsiella, citrobacter, staphylococcus.

Question 4

Aminoglycosides

Answer 4

used for treatment of serious infections that are susceptible to penicillin when penicillin is contraindicated.

Question 5

Aminoglycosides pharmacokinetics

Answer 5

poorly absorbed in GI. Rapidly absorbed after IM injection. Peak level 1 hr. H/L 2-3 hours
*cross placenta
excreted unchanged in urine

Question 6

Gentamicin

Answer 6

many forms-opthalmic, topical, IV, intrathecal, impregnated beads on surgical wire, liposomal injection

Question 7

Streptomycin

Answer 7

very toxic to eighth cranial nerve and kidney

Question 8

Tobramycin

Answer 8

IM or IV. Ophthalmic and nebulizer

Question 9

Aminoglycosides CI

Answer 9

Known allergies, renal or hepatic disease, pre existing hearing loss, active infection with herpes or mycobacterial infection, pregnancy