Aminoglycosides

Question 1

Which drugs are aminoglycosides?

Answer 1

Gentamicin
Streptomycin
neomycin
Tobramycin

Question 2

Which AMG is reserved for TB?

Answer 2

streptomycin

Question 3

What do aminoglycosides do?

Answer 3

they are bactericidal - kills bacteria

Question 4

Can they be taken orally?

Answer 4

given via injection coz they’re not absorbed in the gut

Question 5

What is the main S/E with gentamicin?

Answer 5

ototoxicity and nephrotoxicity
Patient must be aware of any partial hearing loss and vertigo - ototoxicity
OR
if pt is v. dehydrated, nausea vomiting - nephrotoxicity

Question 6

How are AMG excreted?

Answer 6

Renally

Caution in patients with renal impairment

Question 7

What would you need to measure in patients taking AMG?

Answer 7

serum concentration
renal concentration
creatinine clearance should be measured before giving the drug

Question 8

if plasma conc starts going very high, how would you overcome this?

Answer 8

Their dose interval would need to be increased. so if someone was given the drug every 4 hours they would need to be given it every 6 hours
so you dont stop giving the drug, you need to increase the interval so the plasma conc starts to go back to the normal level it should be