Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Analysis > Analysis pre-finals > Flashcards

Analysis pre-finals Flashcards

1
Q

An analyst must possess (blank) and (blank)

A

honesty and integrity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Ability of the product to retain it’s characteristics over time

A

Stability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

An analyst must have the initiative to perform at least how many determinations of the analytical value?

A

2 or 3 trials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Legally recognized compendiums of standard for drugs, which include assays and tests for deterioration of strength and quality and purity.

A

USP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Official compendia are revised every after how many years?

A

1 year

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

It is a solution of known concentration

A

Standard solution

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Volumetric analysis is also known as

A

Titrimetric analysis or titration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Analytical methods that involve separation by extraction, precipitation or other means of the constituent to be determined, either in the natural state or in the form of a compound with definite composition, known to the analyst and then weighing of the resulting product.

A

Gravimetric analysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Determination of the volume of a solution of known concentration required to react with a given amount of the substance to be analyzed.

A

Volumetric analysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

When an analyst is determining strength, potency, and purity of a drug or pharmaceutical product by qualitative and quantitative tests, he/she is doing pharmaceutical ______?

A

Pharmaceutical Assaying

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

An analyst must be able to determine what _____ is/are taking place during an analysis so that he/she can understand the principle in which the analysis is based upon.

A

Chemical reactions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Sum of all factors, or attributes which contribute directly or indirectly to the safety, effectiveness, and reliability of the product.

A

Quality

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

It is a process of removing an appropriate number of items from a population in order to make interferences of the entire solution

A

Sampling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Special crucible with a perforated bottom upon which is bedded a mat of asbestos making it possible to collect, wash, dry and weigh a precipitate in the same crucible

A

Gooch crucible

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Determinate error is also known as what?

A

Systematic or constant errors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the most suitable equipment for procedures that require simple drying without heat?

A

Dessicators

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

A term used to denote the agreement of an experimental data or mean of series of data with the true value?

A

Accuracy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Evaporation of liquids should be carried out in a _______ bath to avoid decomposition and loss of material

A

Water bath

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Molarity values are usually rounded off to the nearest ______ decimal places

A

2 decimal places

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Aside from medicinal agents, their _____ inside the body are also quantitatively determined by quantitative pharmaceutical chemistry through pharmacokinetic testing.

A

Metabolize

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Ability of the product to retain it’s characteristics over time

A

Stability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Characteristics that quality control ascertains in drug products

A

Safe
Effective
Reliable
Stable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What are the General methods employed in quantitative pharmaceutical chemisty

A

Volumetric analysis
Physicochemical analysis
Gravimetric analysis
Special methods

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Aspects of stability in pharmaceutical products

A

Physically stable
Chemically stable
Microbiologically stable
Therapeutically stable
Toxicologically stable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Aside from “analyzed” grade, what other labels should appear on the packaging of chemicals for them to be useful in analytical work

A

USP grade
ACS grade
Reagent grade
Chemical grade

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Titrimetric analysis employed for acidic samples

A

Alkalimetric analysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Most inorganic acid samples employ what indicator in alkalimetric analyses

A

Phenolphthalein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

In basic media, thymolphthalein is colored?

A

Blue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Assay of organic acids employs what specific indicator?

A

Phenolphthalein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Assay of organic bases employ what specifically recommended indicator?

A

Methyl red

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Solution to be titrated where the analyte is deliberately not included

A

Blank solution

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Addition of standard alkali solution to an acidic sample, with the excess alkali being titrated by a standard solution is known as what type of volumetric analysis?

A

Residual alkalimetry

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

What is the color of Bromothymol in HCl?

A

Yellow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Boric acid is a ______ acid

A

Weak acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Metaborate anion is a _____ base

A

Strong base

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

What is the official limit for moisture content in non-aqueous methods?

A

Not more than 0.05%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

In order to correct for the presence of carbon dioxide and water in non-aqueous methods, ______ is/are made.

A

Blank determination

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

What is the most suitable solvent for titrants employed in non-aqueous acidimetry?

A

Dioxane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

What is the most commonly used indicator in non-aqueous acidimetry?

A

Crystal violet/Gentian violet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

What is the color of the endpoint produced if crystal violet as an indicator is used?

A

Emerald green/ blue green

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

What is the primary standard employed for the titrants employed in non-aqueous acidimetry?

A

Potassium biphtalate (KHC8H4O4)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

What is the primary standard employed for the titrants employed in non-aqueous alkalimetry?

A

Benzoic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

Aside from thymol blue, what is the more commonly used indicator for non-aqueous alkalimetry?

A

Azo violet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

What is the color of the endpoint if Azo violet as an indicator is used?

A

Blue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

This indicator is employed in non-aqueous alkalimetric analysis of intermediate-strength to strong acids.

A

Thymol blue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

This indicator is employed in non-aqueous alkalimetric analysis of weak acids

A

O-Nitroaniline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

This indicator is employed in non-aqueous alkalimetric analysis of weak to intermediate strength acids

A

Azo violet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

Method commonly employed in the analysis of nitrogen in organic substances.

A

Kjeldahl method

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

What official method for analysis of nitrogen in samples should you employ if the amount of sample to be used for the analysis is small?

A

Kjeldahl method II / semi-micromethod

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

What is the most common endpoint in non-aqueous alkalimetry?

A

Pink

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

Common reasons for employing residual titrations

A

Not reactive
Not water soluble
Not sharp endpoint

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

Standard solutions employed in non-aqueous acidimetry

A

Perchloric acid
Hydrobromic acid
Organic sulfonic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

Sum of all factors which contribute directly or indirectly to the safety effectiveness and reliability of the product.

A

Quality

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

Drug products should be guaranteed with reasonable limits: FSCP

A

Free of impurities
Stable
Contains the amount of active ingredients as stated on the label
Provides optimal release of active ingredients when the product is administered

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

Determination of strength potency and percentage purity of pharmaceutical drugs

A

Pharmaceutical Assaying

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
56
Q

This covers all matters that influence the quality of a product this also ensures that pharmaceutical products are of the quality required for their intended use

A

Quality assurance

57
Q

Legally recognized compendiums of standards for drugs

A

USP

58
Q

Specifies the tests to be conducted for a particular material or product the procedures and the references for its details and the expected results.

A

Monograph

59
Q

Contains all the tests conducted on a particular material or product to show compliance or non compliance with established standards or specifications

A

Certificate of analysis

60
Q

This assures that policies and neptune ohmic issues associated with manufacturing and distribution of products. Audit and quality monitoring

A

QA functions

61
Q

Testing of rm and representative samples compliance

A

QC functions

62
Q

What are the five capacity of the product to remain its stability

A

Physically stable
chemical stable
microbiologically stable therapeutically stable
toxicologically stable

63
Q

established to assure identity strength quality and purity

A

Stability

64
Q

What are the two errors and estimating expiration date

A

Alpha error: too early
Beta error: too late

65
Q

What is the minimum acceptable potency level

A

90%

66
Q

It is a method of analysis in quantitative pharmaceutical chemistry that is the determination of the value of a standard solution required to react with a given amount of the substance to be analyzed

A

Volumetric analysis

67
Q

Methods of analysis in quantitative pharmaceutical chemistry. analysis based on physical or chemical properties of the substance to be analyzed

A

Physicochemical methods

68
Q

Method of analysis in quantitative pharmaceutical chemistry it is the separation of the constituent and its natural state or in the form of a compound with definite composition to be determined the extraction precipitation or other means and then weighing of the resulting product.

A

Gravimetric analysis

69
Q

Method of analysis in quantitative pharmaceutical chemistry it is the analysis which require a distinct type of technique

A

Special method

70
Q

What are the methods of analysis and quantitative pharmaceutical chemistry

A

Volumetric analysis
physicochemical methods
Gravimetric analysis
special methods

71
Q

What do you call the absorption of water but it does not liquify

A

Hygroscopic

72
Q

This absorb water but liquefies

A

Deliquescence

73
Q

There is no such thing as haste in quantitative work

A

Economy of time

74
Q

Manifest themselves by slight variations in a series of observations made by the same observer under identical conditions

A

Indeterminate errors

75
Q

Recur in a constant manner in each of a series of determinations. Detectable and hence it is possible to eliminate or reduce their effect on the final result

A

Determinate or systematic errors

76
Q

Measures how close the data agrees with each other

A

Precision

77
Q

It is the most common and withstand high temperature and are suitable for use in the ignition of most drugs and precipitates

A

High-grade porcelain crucibles

78
Q

Special crucible with a perforated bottom embedded with a mass of asbestos

A

Gooch filtration crucible

79
Q

Official methods of indirect that a drug be dried to constant weight which means two consecutive waves differ by what of substance taken for determination according to usp and aasc is what

A

Usp—0.5mg
Asc—0.2mg

80
Q

What is the difference in weighing according to usp and asc for a drug to be dried to constant weight

A

USP, NMT 0.5mg
ASC, NMT 0.2mg

81
Q

Methods in which the volume of a solution of known concentration consumed during an analysis is taken as a measure of the amount of active constituent in a sample

A

Titrimetric method of analysis

82
Q

Chemicals that change and color at or very near the point at which equal amounts of titrant and analyze have reacted

A

Indicators

83
Q

Theoretical point at which equivalent amounts of titrant and analyze have reacted

A

Stoichiometric point or equivalence point

84
Q

A color change in the reaction mixture is apparent due to the presence of an indicator

A

Endpoint

85
Q

method where the titrant is directly added to the analyte

A

Direct titrimetric method

86
Q

A carefully measured volume of standard solution known to be chemical e in excess is added first to the analyte and the excess being back titrated by another standard solution

A

Residual or back titration

87
Q

The analyte is treated first with an agent that converts it to an easily measurable substance which can be easily titrated by a standard solution

A

Indirect titration

88
Q

Weight in grams of a substance which is a chemical e equivalent to 1 gram atom of hydrogen

A

Gram equivalent weight GEW

89
Q

Unit of normality

A

mEq/mL

90
Q

Determination of N or M of a solution by using a primary standard or a secondary standard

A

Standardization

91
Q

Carefully weighed sample (solid) of known purity

A

Primary standard

92
Q

A solution of known concentration which can be used to determine the concentration of another solution

A

Secondary standard

93
Q

Weight of a substance chemical e equivalent to 1 ml of a standard solution

A

Tighter or titer value

94
Q

What are the three kinds of volumetric apparatus for delivery of liquid

A

Acid burette—geisler/glass
Universal burette
base burette—rubber/Teflon/morr

95
Q

What are the volumetric apparatus for containing liquid

A

Volumetric flask
Graduated crylinder

96
Q

Precisely manufactured glass tube with graduations enabling measurement of volumes of liquids delivered through a stopcock at the bottom

A

Burets/burette

97
Q

Graduated glass tubes of uniform bore throughout its full length used in the measurement of variable quantities of liquid

A

Burets

98
Q

What error will be introduced if the eye is not at the same level of the meniscus when reading

A

Parallax error

99
Q

What are the best cleaning solutions for volumetric apparatus

A

Na2CR2O7 in H2SO4
^^SODIUM DICHROMATE IN SULFURIC A ID SOLUTION

Na3PO4 — SODIUM PHOSPHATE

SYNTHETIC DETERGENTS

100
Q

What are the chemical reactions used in titrimetry

A

Neutralization rxns (aq. & non. aq)
Redox reactions
Precipitation
Complexation

101
Q

What is the instrument used for endpoint detection (most accurate)

A

Potentiometer

102
Q

What is the three theories on the color change of indicators

A

Physicochemical theory
organic theory
colloidal theory

103
Q

The color change is due to certain ions which causes the appearance of color when increase and disappearance of color or appearance of a different color when decrease

A

Physicochemical theory

104
Q

The color change is due to a change in molecular structure

A

Organic theory

105
Q

The change in color is based on the change in the particle size of the colloidal

A

Colloidal theory

106
Q

When STRONG ACID is to be titrated with strong base or when a strong base is to be titrated with a strong acid what indicators are used

A

Methyl orange
methyl red
Phenolphthalein

107
Q

When weak acid is to be titrated with strong base what indicator must be used

A

Phenolphthalein

108
Q

When a weekdays is to be titrated with a strong acid what indicator must be used

A

Methyl red
Methyl orange

109
Q

What are the standard acid solution in neutralization reaction

A

HCl—hydrochloric acid
H2SO4—sulfuric acid

110
Q

Standard alkaline or base solutions are usually what in neutralization reaction

A

Sodium hydroxide —NaOH
potassium hydroxide—KOH

111
Q

NaOH is more commonly used for what kind of reaction, and KOH is more used for what determination

A

NaOH—neutralization rxn
KOH—fat constants determination

112
Q

Direct or residual titrimetric analysis of bases

A

Acidimetry

113
Q

Equilibrium constant for drives neutralization reactions

A

Ionization constant

114
Q

What is the method 1 of Kjeldahl method called

A

Macromethod or distillation

115
Q

What is the method to of Kjeldahl method called

A

Semi-micromethod

116
Q

Analogous to a see them a tree but the samples or substances under observation are acids

A

Alkalimetry

117
Q

What is the color of thymol blue in acid and in base

A

A-yellow
B-blue

118
Q

Measures how close the data agrees with each other

A

Precision

119
Q

Used to denote the agreement of an experimental data or the mean of a series of data with the true value

A

Accuracy

120
Q

What is the color of Bromothymol blue in acid and base?

A

A—yellow
B—blue

121
Q

What end point is thymolphthalein in acid and base?

A

A—colorless
B—blue

122
Q

Boric acid/ H3BO3 is a _______ acid

A

Weak

123
Q

BO2 / Metaborate is a _____ base = pink color develops before the addition of titrant

A

Strong

124
Q

What is the sequestering agent or complexing agent

A

Glycerin

125
Q

What samples that can be assayed by direct alkalimetric titration (sikat na acid)

A

H2SO4 — oil of vitriol (sulfuric acid)
HCl — muriatic acid
H3PO4 — phosphoric acid

126
Q

Why should carbon dioxide and water as moisture must be excluded

A

They can react with a titrant and there would be an error

127
Q

Why should there be greater care in the control of temperature in non- aqueous titrimetric method

A

Because you’re solvent is organic and if the working environment is hot the solvent can evaporate and when it evaporates it will disappear from the solution and will not react to your titrant

Since organic solvents have high coefficients of expansion

128
Q

Moisture content must be held to less than what according to usp

A

0.05%

129
Q

o-nitroAnilinE

A

For very weak acids

130
Q

AZo vIolet

A

For weak or intermediate strength acids

131
Q

Thymol blue

A

Intermediate strength to strong acids

132
Q

Analytical methods that require the formation of relatively insoluble substances or precipitates cause the reaction to go to sufficient completion

A

Precipitimetry

133
Q

Equilibrium constant that drives the reaction to completion in precipitimetry is known as

A

Solubility product constant

134
Q

Endpoint in volumetric precipitation may be determined by:

A

Cessation of precipitation or appearance of turbidity
Use of indicators
Instrumental methods (potentiometer)

135
Q

What are the methods employed in precipitimetric titration

A

Mohr’s method
Volhard’s method
Fajan’s method
Liebig’s method

136
Q

What is the indicator of morh’s method

A

Potassium cromate

137
Q

endpoint of Azo violet and thymol blue

A

Clear blue

138
Q

Commonly employed indicators in non aqueous alkalimetry

A

Azo viet
thymol blue

Analysis (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions