Anti-Arrhythmic Drugs

Question 1

Class 1 Antiarrhythmics

Answer 1

Sodium Channel Blockers

Question 2

Lidocaine

Answer 2

Class 1B

Blocks Na Channels to increase threshold
Slows rate of phase 0
Use dependent

Ventricular arrhythmias

Question 3

Sotalol

Answer 3

Class 3 (K+ blocker)
Phase 3: delays repolarization and lengthens APD

Question 4

Amiodarone

Answer 4

Class 3 (most common drug) (K+ blocker)
Phase 3: delays repolarization and lengthens APD

Ventricular arrhythmias, atrial fibrillation/flutter.

SE because of iodine, risk of TdP

Question 5

Dronedarone

Answer 5

Class 3 (trial phase) (K+ blocker)
Phase 3: delays repolarization and lengthens APD

Less toxicity than amiodarone.

Severe VT/VF.

Question 6

Propafenone

Answer 6

Class 1C

Question 7

Beta-Blockers

Answer 7

Class 2

Negative chronotropic and ionotropic effects
Adjunctive
Contraindicated: Acute heart failure, asthma, arrhythmias with AV block

Question 8

Adenosine

Answer 8

Like ACh

Decreases sinus rate and AV conduction, anti-ischemic.

Used for supraventricular tachy.

Question 9

Digoxin

Answer 9

Increased vagal tone -> slows AV conduction

Occasionally for A fib, increases contractility.

Toxic beyond tiny therapeutic window.