Anticoagulant Drugs Flashcards
ASA
Target: COX
Irreversible
Antidote: Platelets
MI, stroke, VTE
NSAIDs
Target: COX
Reversible
Antidote: Platelets/time
Dipyridamole
Target: Phosphodiesterase
Reversible
Antidote: Platelets/time
Clopidogrel, Prasugrel, Ticagrelor
Target: ADP receptor
Clopidogrel and Prasugrel = Irreversible
Ticagrelor = Reversible
Antidote: Platelets/time
Anti-GPIIb/IIIa
Target: Xa
Irreversible
Antidote: Platelets
UF Heparin
Target: II, Xa
Antidote: Protamine
Monitoring: aPTT
Dalteparin
LMWH (different peak times) Target: Xa Antidote: Protamine Good for DVT Monitoring: Anti Xa
DVT, PE, CAD, Angioplasty/stenting procedures.
Danaproid
Heparan Sulfate
Target: IIa/Xa
Antidote: None
Coumadin
Decreases Vit K Factors Transiently hypercoagulable Teratogenic Antidote: PCC > FFP and Vit K Monitoring: PT
Dabigatran
NOAC. Pro Drug. Target: II Antidote: aPCC Monitoring: Thrombin time
A Fib, ortho surg prophylaxis, VTE.
Enoxaparin
NOAC - LMWH (different peak times) Target: Xa Antidote: Protamine Good for DVT Monitoring: Anti Xa
DVT, PE, CAD, Angioplasty/stenting procedures.
Tinzaparin
LMWH (different peak times) Target: Xa Antidote: Protamine Good for DVT Monitoring: Anti Xa
DVT, PE, CAD, Angioplasty/stenting procedures.
Fondaparinux
NOAC - LMWH (different peak times) Target: Xa Antidote: Protamine Good for DVT Monitoring: Anti Xa
DVT, PE, CAD, Angioplasty/stenting procedures.
Rivaroxaban
NOAC.
Target: Xa
Antidote: PCC
Monitoring: PT, Anti Xa
Apixaban
NOAC.
Target: Xa
Antidote: PCC
Monitoring: Anti Xa