Antiemetic & Antinausea Flashcards

1
Q

Types of antiemetic & anti nausea drugs

A

-anticholinergic drugs
-antihistamines (histamin 1 receptor blockers)
-antidopaminergic
-neurokinin antagonist
-prokinetic
-serotonin blockers
-tetrahydrocannabinoids

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2
Q

Main anticholinergic drug

A

Scopolamine bromide

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3
Q

Site of action of scopolamine

A

Inner ear labyrinth

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4
Q

Main antihistamine drugs

A

Dimenhydrinate (Gravol)
Diphenhydramine (Benadryl)

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5
Q

Dimenhydrinate & diphenhydramine indication

A

Motion sickness, nonproductive cough, allergy symptoms, sedation

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6
Q

Main antidopaminergic drugs

A

Prochlorperazine (Proclorazine)

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7
Q

Prochlorperazine indication

A

Psychotic disorders, intractable hiccups in chemotherapy

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8
Q

Main neurokinin receptor antagonist

A

Aprepitant (Emend)

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9
Q

Aprepitant indication

A

Inhibit acute & delayed phases of chemotherapy-induced emesis

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10
Q

Main prokinetic drugs

A

Metoclopramide (Metonia)

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11
Q

Metoclopramide indication

A

GI reflux, delayed GI emptying (stimulates peristalsis = enhance stomach emptying)

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12
Q

Adverse effect of metoclopramide form long term use

A

Irreversible tardive dyskinesia*

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13
Q

Main serotonin blocker

A

Ondansetron (Zofran)

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14
Q

Ondansetron indication

A

Nausea & emesis in chemotherapy and postop

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15
Q

Main drug for tetrahydrocannabinoids

A

Medical marihuana

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16
Q

Marihuana indication

A

nausea & emesis from chemotherapy and anorexia associated with weight loss in AIDS

17
Q

Doxylamine succinate & pyridoxine hydrochloride indication

A

morning sickness with pregnancy (Combination known as Diclectin)

18
Q

Ginger indication

A

Nausea & emesis from chemotherapy, morning sickness, motion sickness

19
Q

Ginger adverse effects

A

anorexia, nausea, emesis, skin reactions

20
Q

Ginger interactions

A

Increased oral med absorption
Increased bleeding risk with anticoagulants

21
Q

Patient education on alcohol use effects

A

May cause severe CNS depression

22
Q

Patient education on main adverse effect of drugs & interventions

A

Drowsiness - warn about driving or performing hazardous tasks

Hypotensive effects: avoided by changing position slowly

23
Q

When should antiemetics be given in chemotherapy

A

Given 30-60 min before chemotherapy begins