Antiepileptic Hypersensitivity Syndrome

Question 1

What is antiepileptic hypersensitivity syndrome ?

Answer 1

Rare but fatal syndrome associated with some antiepileptic drugs
1. Fever
2. Rash
3. Lymphadenopathy
Other systemic signs = liver dysfunction, hematological, renal, pulmonary, multi-organ failure
Symptoms usually 1-8 weeks of exposure

Question 2

What drugs?

Answer 2

1. Carbamazepine
2. Phenytoin
3. Phenobarbital
4. Primidone
   * CP3
5. Lamotrigine
6. Oxcarbazepine
7. Lacosamide
   * LOL
8. Rufinamide