Antifungals

Question 0

Miconazole

Answer 0

Oropharyngeal candidiasis

1.25-2.5ml QID for 7-14 days

Question 1

Fluconazole

Answer 1

Mucocutaneous candidiasis
Vaginal candidiasis
Tinea corporis resistant to topical tx

50-200mg daily, up to 400mg daily
150mg as a single dose

FBC, liver function, anaphylaxis, QT interval prolongation, peripheral neuropathy (long term use), renal function

Question 2

Amphoteracin

Answer 2

Oral candidiasis
Severe systemic fungal infections

1 lozenge (10mg) QID for 7-14 days

Renal function, electrolytes, FBC, hepatic function

Question 3

Griseofulvin

Answer 3

Dermatophyte infection of scalp, skin, nails where topical tx has failed or inappropriate

500mg daily for 4-6 weeks (skin, scalp)
1g daily for up to 12 months (nails)

FBC, hypersensitivity, additional contraception during and 4 weeks after

Question 4

Nystatin

Answer 4

Oropharyngeal candidiasis
Intestinal candidiasis

100 000 units QID for 7-14 days, and for several days after symptoms disappear

Question 5

Terbinafine

Answer 5

Tinea of the nail
Dermatophyte infection of the skin, groin, feet where topical tx is ineffective or inappropriate

250mg daily (up to 6-12 weeks for nails)

Liver function, renal function, FBC, hypersensitivity, parasthesia