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Pharm > antifungals > Flashcards

antifungals Flashcards

1
Q

MOA

Amphotericin B

A

complexes with ergosterol; makes pores

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2
Q

S.e.

Amphotericin B deoxycholate

A

nephrotoxicity

fever/chill and hypotension

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3
Q

MOA

fluconazole

A

block sterol synthesis by inhibit 14 d meth (CYP 450 enzyme)

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4
Q

MOA

Caspofungin

A

block synthesis of beta glucan, part of fungal cells all

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5
Q

Drug of choice:

invasive aspergillosis

A

voriconazole

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6
Q

MOA

Itraconazole

A

block sterol synthesis by inhibit 14 d meth (CYP 450 enzyme)

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7
Q

Drug of choice

Histoplasmosis

A

Itraconazole

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8
Q

S.e.

Male gyenocomastia

A

Ketoconazole

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9
Q

Drug of choice

Cryptococcal meningitis

A

amphotericin b plus flucytosine

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10
Q

MOA

Flu cytosine

A

inhibit fungal dna / rea synthesis

anti metabolite

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Pharm (6 decks)

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