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PHRM > Antiinflammatory And Autacoids > Flashcards

Antiinflammatory And Autacoids Flashcards

1
Q

Excess production of histamines is measured in the urine by

A

Imidazole acetic acid

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2
Q

H3 antagonist

A

Clobenpropit

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3
Q

Classic demonstration of histamine effect

A

Triple response

Wheal
Flush
Flare

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4
Q

The triple response is mediated primarily by which H receptor type? How many histamine receptors are there?

A

H1

4

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5
Q

Describe all histamine receptor, distribution, and effect

A

H1 smooth muscle - pain itching bronchoconstriction, vasodilation, local edema

H2 stomach heart mast cells - gastric acid secretion, cardiac stimulation

H3 nerve endings - modulation of other NTs

H4 leukocytes - leukocyte chemotaxis

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6
Q

Most important amine autacoids

A

Histamine and serotonin

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7
Q

First generation antihistamines

A

Diphenhydramine

Chlorpheniramine
Cyclizine
Meclizine
Promethazine
Hydroxyzine
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8
Q

Similarities and differences in the MOA of first generation and second generation antihistamines

A

Similarities: both on H1 receptor

Differences: 1st gen: CNS and peripheral with anti motion sickness effect

2nd gen: peripheral only

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9
Q

_________ from interaction between azoles/erythromycin and terfenadine/astemizole

A

Fatal arrythmias

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10
Q

2nd gen antihistamines

A 
Cetirizine
Levocetirizine
Loratidine
Deslora
Fexofenadine
Terfenadine
Astemizol
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11
Q

H2 receptor antagonist

A

Cimetidine, ranitidine, famotidine, nizatidine

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12
Q

H2 antagonist that causes gynecomastia

A

Cimetidine

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13
Q

Chemical name of serotonin

A

5 hydroxytryptamine or 5-HT

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14
Q

Excess production of serotonin is detected by _____ in the urine

A

5 hydroxy indole acetic acid (5-HIAA)

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15
Q

Serotonin receptor found in the brain

A

5 HT1D

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16
Q

5HT2 receptors are found in the

A

Smooth muscle and platelets

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17
Q

5 HT3 is found in the

A

Area postrema, sensory and enteric nerves

18
Q

Prototype antagonis of 5HT2

A

Ketanserin

19
Q

Secondary messenger of 5HT3

A

Ligand gated ion channel

20
Q

5HT4 prototype antagonist

A

Tegaserod (partial agonist)

21
Q

3 things that cause platelet aggregation.

A

TXA2
Serotonin
ADP

22
Q

3 things that inhibit plateley aggregation

A

PGI2
cAMP
Adenosine

23
Q

DOC for acute migraine, cluster headache

A

Sumatriptan

24
Q

Moa of sumatriptan

A

5HT 1D/1B receptor agonists

25
Q

MOA of ondansetron

A

5HT3 receptor antagonist

26
Q

5HT3 receptor antagonist user for irritable bowel disease

A

Alosetron

27
Q

5HT3 receptor antagonist that cause QRS and QT prolongation? Constipation?

A

Dolasetron

Alosetron

28
Q

Complex molecules are produced by a fungus found in wet or spoiled grain

A

Ergot alkaloids

29
Q

Ergotism

A

Hallucinations and psychotic like symptoms

30
Q

Classification of ergot alkaloids

A

Vasoselective
Uteroaelective
CNS selective

31
Q

5HT2 antagonist ergot alkaloid that is vasoselective

A

Ergotamine
Dihydroergotamine
Methysergide

32
Q

5Ht2 antagonist ergot alkaloid that is uteroselective

A

Ergonovine

Methylergonovine

33
Q

antidote for ergotamine is

A

Nitroprusside

34
Q

Histamine is metabolized by the enzymes

A

MAO and DAO

35
Q

Potent leukotriene bronchdilators for asthma

A

LTC4
LTD4
LTE4

36
Q

Leukotriene mediator for chemotaxis

A

LTB4

37
Q

Eicosanoid responsible for plateley aggregation

A

TXA2

38
Q

Eicosanoid responsible for maintaining PDA

A

PGE1

39
Q

Eicosanoid responsible for vascular smooth muscle relaxation particularly peripheral, coronary, and pulmonary blood vessels.

A

PGI2

40
Q

Eicosanoid responsible for increasing uterine tone (uterotonic)

A

PGE2

PHRM (14 decks)

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