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Flashcards in Antiinflammatory And Autacoids Deck (40):
1

Excess production of histamines is measured in the urine by

Imidazole acetic acid

2

H3 antagonist

Clobenpropit

3

Classic demonstration of histamine effect

Triple response

Wheal
Flush
Flare

4

The triple response is mediated primarily by which H receptor type? How many histamine receptors are there?

H1

4

5

Describe all histamine receptor, distribution, and effect

H1 smooth muscle - pain itching bronchoconstriction, vasodilation, local edema

H2 stomach heart mast cells - gastric acid secretion, cardiac stimulation

H3 nerve endings - modulation of other NTs

H4 leukocytes - leukocyte chemotaxis

6

Most important amine autacoids

Histamine and serotonin

7

First generation antihistamines

Diphenhydramine

Chlorpheniramine
Cyclizine
Meclizine
Promethazine
Hydroxyzine

8

Similarities and differences in the MOA of first generation and second generation antihistamines

Similarities: both on H1 receptor

Differences: 1st gen: CNS and peripheral with anti motion sickness effect

2nd gen: peripheral only

9

_________ from interaction between azoles/erythromycin and terfenadine/astemizole

Fatal arrythmias

10

2nd gen antihistamines

Cetirizine
Levocetirizine
Loratidine
Deslora
Fexofenadine
Terfenadine
Astemizol

11

H2 receptor antagonist

Cimetidine, ranitidine, famotidine, nizatidine

12

H2 antagonist that causes gynecomastia

Cimetidine

13

Chemical name of serotonin

5 hydroxytryptamine or 5-HT

14

Excess production of serotonin is detected by _____ in the urine

5 hydroxy indole acetic acid (5-HIAA)

15

Serotonin receptor found in the brain

5 HT1D

16

5HT2 receptors are found in the

Smooth muscle and platelets

17

5 HT3 is found in the

Area postrema, sensory and enteric nerves

18

Prototype antagonis of 5HT2

Ketanserin

19

Secondary messenger of 5HT3

Ligand gated ion channel

20

5HT4 prototype antagonist

Tegaserod (partial agonist)

21

3 things that cause platelet aggregation.

TXA2
Serotonin
ADP

22

3 things that inhibit plateley aggregation

PGI2
cAMP
Adenosine

23

DOC for acute migraine, cluster headache

Sumatriptan

24

Moa of sumatriptan

5HT 1D/1B receptor agonists

25

MOA of ondansetron

5HT3 receptor antagonist

26

5HT3 receptor antagonist user for irritable bowel disease

Alosetron

27

5HT3 receptor antagonist that cause QRS and QT prolongation? Constipation?

Dolasetron
Alosetron

28

Complex molecules are produced by a fungus found in wet or spoiled grain

Ergot alkaloids

29

Ergotism

Hallucinations and psychotic like symptoms

30

Classification of ergot alkaloids

Vasoselective
Uteroaelective
CNS selective

31

5HT2 antagonist ergot alkaloid that is vasoselective

Ergotamine
Dihydroergotamine
Methysergide

32

5Ht2 antagonist ergot alkaloid that is uteroselective

Ergonovine
Methylergonovine

33

antidote for ergotamine is

Nitroprusside

34

Histamine is metabolized by the enzymes

MAO and DAO

35

Potent leukotriene bronchdilators for asthma

LTC4
LTD4
LTE4

36

Leukotriene mediator for chemotaxis

LTB4

37

Eicosanoid responsible for plateley aggregation

TXA2

38

Eicosanoid responsible for maintaining PDA

PGE1

39

Eicosanoid responsible for vascular smooth muscle relaxation particularly peripheral, coronary, and pulmonary blood vessels.

PGI2

40

Eicosanoid responsible for increasing uterine tone (uterotonic)

PGE2