Antimicrobials

Question 1

B-lactamase resistant penicillins

Answer 1

Methicillin, Oxacillins (Cloxacillin, Flucloxacillin)

-Co-amoxiclav

Question 2

Amino penicillins

Answer 2

Ampicillin, Amoxicillin

-broad spectrum G+ & G-

Question 3

Ureido penicillins

Answer 3

• azlocillin, mezlocillin, piperocillin - semi-synthetic

- increased cover against pseudomonas

Question 4

Penicillin resistance

Answer 4

1. Enzyme mediated
   - G+ contains penicillinases
   - G- contains B-lactamases
2. Reduced entry change in membrane permeability
3. Altered target site (binding proteins)
4. Development of altered metabolic pathway

Question 5

Cephalosporins

Answer 5

• similar to penicillin

- Cefoxitin - excellent against anaerobes

Question 6

Penicillin

Answer 6

• inhibits cell wall synthesis (peptidoglycan transpeptidation)
• G+ spectrum, some G- cocci
• Pen G (acid labile) & Pen VK (acid stable)