Antimicrobials Flashcards
1
Q
Tetracyclines
MOA?
A
Binds 30s subunit and prevents binding of aminoacyl TRNA to acceptor site. Bacteriostatic
2
Q
Tetracycline: Used for refractory SIADH
A
Demeclocycline
3
Q
Tetracycline with broadest spectrum
A
Tigecycline
4
Q
Tetracycline: Photosensitivity
A
Demeclocycline
5
Q
Tetracycline safest for patients with renal impairment
A
Doxycycline (biliary clearance)
6
Q
Tetracycline:
Resistance mechanisms?
A
Efflux pumps
Inhibition of binding site
7
Q
Tetracycline:
Most potent? Able to achieve therapeutic concentrations in brain and CSF
A
Minocycline
8
Q
Macrolides
Used for macrolide resistance
A
Telithromycin
9
Q
Macrolides
Mechanism of resistance
A
Efflux pumps
Methylase enzyme