Antimicrobials Flashcards

1
Q

Tetracyclines

MOA?

A

Binds 30s subunit and prevents binding of aminoacyl TRNA to acceptor site. Bacteriostatic

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2
Q

Tetracycline: Used for refractory SIADH

A

Demeclocycline

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3
Q

Tetracycline with broadest spectrum

A

Tigecycline

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4
Q

Tetracycline: Photosensitivity

A

Demeclocycline

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5
Q

Tetracycline safest for patients with renal impairment

A

Doxycycline (biliary clearance)

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6
Q

Tetracycline:

Resistance mechanisms?

A

Efflux pumps

Inhibition of binding site

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7
Q

Tetracycline:

Most potent? Able to achieve therapeutic concentrations in brain and CSF

A

Minocycline

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8
Q

Macrolides

Used for macrolide resistance

A

Telithromycin

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9
Q

Macrolides

Mechanism of resistance

A

Efflux pumps

Methylase enzyme

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