Antimicrobials- Nuclic Acid Synthesis Flashcards
Name antibiotics that inhibit nuclic acid synthesis in bacteria
1.quinolones
2. Sulphanamide
3.Azoles
What is the first quinolones
Nalidixic acid
Name the quinolone that is not needed to dose reduction in renal failure patients and give the reason to it.
Moxifloxacin
Because it is predominantly metabolized in liver.
What is the most common drug used in UTI and mention its half life and dose
Norfloxacin
T1/2 is 3hr
Dose- 400mg bd
‘Name the quinolones used to treat for prostatitis
- Norfloxacin
- Ciprofloxacin
- Ofloxacin
- Levofloxacin
Name the first line quinolone to treat typhoid fever
Ciprofloxacin
Name the main quinolones used to treat RTI Patients.
Ciprofloxacin and levofloxacin
Name the quinolone that is drug of choice for prophylaxis and treatment of anthrax
Ciprofloxacin
What are the quinolones that are used in topical preperations for eye infections.
Ciprofloxacin
Levofloxacin
Ofloxacin
Name the adverse effects of quinolones
GI upset
Allergic reaction
Photosensitivitybreaction
CNS -Anxiety, dizziness, headache, convulsion, confusion
Reversible anthropathy in weight bearing joints
Tendinitis and tendon rupture
Name the patients that are having high risk for fluoroquinolone induced convulsions
Patients with a history of epilepsy
Name the patients that are not recommending usage of quinolones
Children and adolescents not recommended for under 18yrs
Pregnancy.
What is the drug that may cause haemolysis in glucose 6-phosphate deficiency patients.
Nalidixic acid
Name the drug that is having greater activity against streptococcus pneumoniae
Levofloxacin
Name the quinolone that is recommended for second line treatment for upper and lower respiratory infection
Moxifloxacin
