Antiplatelet Agents

Question 1

How does aspirin work?

Answer 1

it inhibits COX-1 synthesis of thromboxane in platelets

Question 2

What drug inhibits COX-1 synthesis of thromboxane in platelets?

Answer 2

aspirin

Question 3

How do Clopidogrel (Plavix), Prasugrel (Effient), and Ticagrelor (Brilinta) work?

Answer 3

they’re ADP (purinergic-P2Y12) receptor antagonists that interfere with ADP-induced platelet aggregation.

Question 4

These drugs are ADP (purinergic-P2Y12) receptor antagonists that interfere with ADP-induced platelet aggregation.

Answer 4

Clopidogrel (Plavix), Prasugrel (Effient), and Ticagrelor (Brilinta)

Question 5

How does Dipyridamole (Persantine) work?

Answer 5

Blocks phosphodiesterase breakdown of cAMP, elevating cAMP levels and potentiating prostacyclin’s anti-aggregatory action

Question 6

This drug blocks phosphodiesterase breakdown of cAMP, elevating cAMP levels and potentiating prostacyclin’s anti-aggregatory action.

Answer 6

Dipyridamole (Persantine)

Question 7

How do Abciximab (Reopro), Eptifibatide (Integrelin), and Tirofiban (Aggrastat) work?

Answer 7

Blocks IIb/IIIa receptors on platelet thus preventing integrin and fibrinogen binding that facilitates aggregation (platelet-platelet binding).

Question 8

These drugs block IIb/IIIa receptors on platelet, thus preventing integrin and fibrinogen binding that facilitates aggregation (platelet-platelet binding).

Answer 8

Abciximab (Reopro), Eptifibatide (Integrelin), and Tirofiban (Aggrastat)