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Pharm - Psych > Antipsychotics > Flashcards

Antipsychotics Flashcards

1
Q

anti-psychotics should be used to treat dementia in the older adult, t or f

A

false - if must use a-typical class

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2
Q

other uses for anti-psychotic agents

A

tourettes syndrome

prevention of emesis

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3
Q

2 classes of anti-psychotics

A

conventional and atypical; 1st gen./2nd gen.

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4
Q

oldest anti-psychotic drug

A

Thorazine

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5
Q

conventional (1st generation) anti-psychotics MOA

A

block receptors for dopamine, acetylcholine, histamine, and NE

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6
Q

conventional/1st gen. drugs can cause (s/e)

A

EPS - extra-pyramidal symptoms

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7
Q

conventional/1st gen drugs

A

*haldol, *thorazine, loxitane

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8
Q

how long before we see positive symptoms go away on 1st gen anti-psychotics

A

full effect = a few months
initial effect = 1-2 days
improvement 2-4 weeks

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9
Q

2nd gen. anti-psychotics MOA

A

moderate blockade of dopamine

stronger blockade of serotonin (mood)

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10
Q

2nd gen. anti-psychotics have a high risk for which s/e

A

metabolic syndrome (dyslipidemia, diabetes)

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11
Q

2nd gen. anti-psychotic drugs

A

*clozaril, zyprexa, abilify, seroquel, risperdal

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12
Q

serotonin (mood) correlates with what schizophrenic symptom

A

negative symptoms

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13
Q

***2nd gen/atypical anti-psychotics effect negative symptoms more effectively, t or f

A

true

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14
Q

what are metabolic syndrome symptoms

A

weight gain

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15
Q

classification of FGA’s is by what

A

potency = the amt of drug needed to achieve therapeutic effect

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16
Q

***EPS symptoms extra-pyramidal symptoms

A

acute dystonia - severe spasm in neck/face/jaw
parkinsonism - shuffling gait, pill rolling, drooling
akathisia - profound restlessness (tapping leg)
tardive dyskinesia - jerky movements, lip smacking

17
Q

***trt for acute dystonia (EPS symptom)

A

IM Benadryl

18
Q

2nd generation anti=psychotics are less likely to cause EPS symptoms, t or f

A

true

19
Q

*once someone gets tardive dyskinesia they have it forever, t or f

A

true - not curable - no trt

20
Q

trt for pseudoparkinsonism (EPS syndrome)

A

chg to 2nd generation anti-psychotics

21
Q

trt for akathisia (EPS syndrome)

A

beta blockers, benzos

22
Q

how do you prevent EPS symptoms

A

prescribe lowest dose possible - can take yrs to develop

23
Q

adverse effects of 1st generation anti-psychotics

A

anticholinergic effects

24
Q

what are anti-cholinergic effects

A 
dry mouth, blurred vision, constipation, urinary retention
orthostatic hypertension
neuro-endocrine effects (men lactating)
seizures
sexual dysfunction
photo-sensitivity (wear sunscreen)
dysrhytmias
25
Q

what would we do if pt complains of anti-cholinergic symptoms

A

re-hydrate, suck on hard candies

educate on s/e

26
Q

a rare but serious adverse effect of FGA

A

neuroleptic malignant syndrome (NMS) - autonomic hyperactivity

27
Q

trt for neuroleptic malignant syndrome (NMS)

A

stop the drug

28
Q

anti-psychotic drugs are considered very safe, t or f

A

true

29
Q

thorazine s/e

A

orthostatic hypo-tension, anticholinergic effects and sedation

30
Q

haldol is most likely to cause these s/e

A

eps, sedation

31
Q

what other disorder is haldol commonly prescribed for

A

tourettes

32
Q

clozapine is used

A

when everything else has failed

33
Q

clozapine MOA

A

blocks dopamine and serotonin

34
Q

primary s/e of clozapine

A

agranulocytosis, metabolic syndrome

35
Q

if you are on clozapine what are you having done weekly

A

wbc count draws for first 6 months of trt

36
Q

what is the clozaril protocol

A

wkly wbc ct - 1st 6 months of trt (if

37
Q

what is a depot preparation

A

long acting injectable long-term maint. therapy for schizo

38
Q

You have been assigned to care for Jim. He is 29 years old and has been diagnosed with schizophrenia. Jim has been prescribed chlorpromazine (Thorazine). He lives with his parents, who have no experience dealing with behavioral health issues. You have been asked to talk with Jim’s family. His parents have questions about the side effects of chlorpromazine. While Jim is in a group session, you meet with his parents. How would you best answer their questions?

A

orthostatic hypotension, sedation, anticholinergic effects

Monitor Jims BP

Pharm - Psych (2 decks)

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