Apoptosis Flashcards

1
Q

¿Que la caracteriza?

A

Membrana intacta
Célula y sus fragmentos ingeridos
NO inflamación

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2
Q

Caspasas importantes

A

Intrínseca: 2 y 9
Extrínseca: 8 y 10
3,6 y 7

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3
Q

Proteínas antiapoptosicas

A

Mantienen permeabilidad membrana, evitan escape proteínas inductoras de muerte
Bcl2 y Bclx1

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4
Q

Proteínas proapoptosicas

A

Forma canales en la membrana > paso citocromo C
Bax y bak

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5
Q

Proapoptosicas BH3

A

Sensores del estrés y daño celular, activa proteínas proapoptosicas

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6
Q

Apoptosoma

A

Citocromo C + factor inductor de apoptosis + procaspasa 9

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7
Q

Vía intrínseca

A

Daño (membrana, ADN, [] proteínas mal plegadas)
+ Permeabilidad mitocondrial
Salida de moléculas > smacD, apoptosoma
= activa caspasa 9 = activa más caspasas 3, 6, 7

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8
Q

Vía extrínseca

A

Activada por señales externas

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