Assisted conception Flashcards

1
Q

Advice prior to commencing ACT (6)

A
Alcohol- fewer than 4 units  per week
BMI 19-29
Stop smoking
Folic acid 0.4mg/day
Rubella check +/- immunization
Cervical smears up to date
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2
Q

Main indications for intra-uterine insemination (3)

A

Male factor
Endometriosis
Unexplained

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3
Q

What does Buserelin do and when should it be commenced?

A

Causes down-regulation of GnRH receptors, thereby reducing FSH/LH release. Day 21 of the cycle

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4
Q

When should the baseline scan for IVF be undertaken?

A

2-3 weeks after commencing Buserelin nasal spray

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5
Q

After the baseline scan, how is ovarian stimulation achieved?

A

Daily injections of FSH

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6
Q

When should the action scan be taken?

A

8 or 9 days after FSH is commenced

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7
Q

What does hCG achieve in IVF?

A

Mimics the LH spike

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8
Q

When are eggs collected?

A

About 36 hours after hCG

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9
Q

How many embroys should be transferred?

A

Under age 40-maximum 2

Over age 40- maximum 3

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10
Q

How is the luteal phase mimicked in IVF?

A

Cyclogest (progesterone) pessary for two weeks after embryo transfer

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11
Q

What features of the partner/donor sperm are assessed? (4)

A

Volume, density, motility, progression

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12
Q

What are the indications for intracytoplasmic sperm injection?

A
Male factor (severe)
Previous failed IVF
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13
Q

How might azoospermia be managed in the context of IVF/ICSU?

A

Surgical sperm aspiration

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14
Q

How does the method for ICSU differ from IVF?

A

The egg is stripped, the sperm are immobilised and one single sperm is injected

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15
Q

What is the underlying cause of ovarian hyperstimulation syndrome?

A

Excess stimulation -> excess follicles and enlarged ovaries. Release of vasoactive substances

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16
Q

Symptoms of OHSS (3)

A

Abd pain
Nausea and vomiting
Breathlessness

17
Q

How might OHSS be avoided?

A

“Coasting”- withdraw gonadotrophin and postpone hCG until oestrogen goes down

18
Q

Monitoring of OHSS (4)

A

FBC
U&Es
Creatinine
LFTs

19
Q

Other potential problems (other than OHSS) associated with ACT (5)

A
Multiple pregnancy
Ectopic pregnancy
Surgical risks (egg recovery, sperm aspirate)
Non-continuing pregnancy
Increased complications of pregnancy