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From Flashcardlet > Autonomic Drugs > Flashcards

Autonomic Drugs Flashcards

1
Q

Alpha 1 Functions

A
  • Dilate Eye (myadriasis)
  • Constrict arteries and Veins
  • Constrict Trigone in bladder
  • Constrict Sphincters in GI
  • Cause Ejaculation
  • Constrict vasculature in nasal mucosa
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2
Q

Alpha 2 Functions

A
  • Constrict Arteries and Veins

- Decrease GI Motility (Minor)

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3
Q

Beta 1 Functions

A
  • Increase Force of Contraction of Heart, incrase rate, automaticity, and impulse conduction
  • Increase Renin secretion from kidney resulting in vasoconstriction
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4
Q

Beta 2 Functions

A
  • Dilate Bronchioles
  • Dilate Arteries and Veins (Overshadowed by alpha mediated constriction)
  • Decrease GI Motility (Minor)
  • Relax Detrussor Muscle of Bladder
  • Relax Pregnant Uterus
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5
Q

Beta 3 Functions

A

-Relax Detrussor Muscle in Bladder

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6
Q

Epinephrine

A
  • Released from Chromaffin cells in Adrenal Gland
  • Agonist to all alpha and beta receptors
  • More potent to beta, less potent to alpha
  • Poorly bioavailable when taken orally
  • Used in Cardiac Arrest patients to restart heart
  • Used to treat open angle glaucoma because of myadriasis and opening of trabecular network
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7
Q

Norepinephrine

A
  • Released from post-ganglionic sympathetic neurons onto effector tissue
  • Agonist to all receptors
  • Stronger against alpha than epinephrine
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8
Q

Isoproterenol

A

-Agonist to B1, B2, and B3

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9
Q

Phenylephrine

A
  • Specific agonist to alpha 1
  • Used to stop tachychardic arrythmias because of baroreceptor induced decrease in HR
  • Used to treat hypotension
  • Used to treat runny nose, constricts vasculature in nose
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10
Q

Clonidine

A
  • Agonist CNS acting specific to alpha 2

- Decreases sympathetic outflow from the brain

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11
Q

Oxymetazoline

A
  • Agonist to peripheral alpha 2
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12
Q

Dobutamine

A
  • Agonist Specific for B1, but also works some on alpha 1 and 2 and Dopamine Receptors
  • Used in Cardiogenic Shock (along with Dopamine) (increase CO and PR)
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13
Q

Albuterol

A
  • Agonist specific for B2 receptors

- Used to treat Asthma

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14
Q

Mirabegron

A
  • Agonist Specific for B3 receptors

- Used to treat overactive bladder

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15
Q

Amphetamine

A

-Causes release of Norepi and Epi

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16
Q

Methylphenydate

A
  • Causes release of Epi and Norepi

- Used to treat ADHD

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17
Q

Tyramine

A
  • Causes release of Nor Epi and Epi
  • Found in Meats and Cheeses, usually metabolized by MAO, but MAO inhibitors (Phenilzine) prevent that and can have disasterous Drug Drug interactions
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18
Q

TCA (Imiprimine) and Cocaine

A

Block uptake of Norepi and cleft

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19
Q

Ephedrine and Pseudoephedrine

A

-Works as a sympathomimetic and releaser of Norepi/Epi

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20
Q

Carvedilol Labetalol

A
  • Antagonist of alpha 1 receptors and beta receptors
  • 3rd generation, mixed alpha beta antagonism causes decreased CO and PR
  • Used to treat hypertension
  • Treat congestive heart failure
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21
Q

Propranolol

A
  • Antagoinst of all beta receptors
  • 1st generation
  • Used to treat hypertension
  • Can be used to treat arrythmias
  • Glaucoma, decreases the production of aqueos humor
  • Used to reduce muscle tremor
  • Used as a prophylaxis to treat migrane
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22
Q

Phentolamine, Phenoxybenzamine

A
  • Antagoinst to both alpha receptors
  • Phenoxybenzamine binds irreversibly to receptors
  • Blockade of alpha receptors with subsequent adimistration of epinephrine results in vasodilation and a drop in BP
  • Used to Treat Raynaud’s and frostbite, prevents in extremities
  • Can treat impotence, allows vasodilation and erection
23
Q

Terazosin Tamsulosin

A
  • Antagoinst to alpha 1 receptors
  • 2nd generation
  • Used to Treat Hypertension
  • Used to treat BPH, relaxes smooth muscle around urethra that constricts the urethra die to an enlarged prostate
24
Q

Pindolol

A

-Antagoinst to beta receptors but causes low level activation

25
Q

Metoprolol Atenolol

A
  • Antagonist to B1 specifically
  • Used to treat hypertension
  • Used to treat angina pectoris
  • Currently given after MI, but use is being questioned
26
Q

Reserprine

A

-Blocks VMAT and prevents dopamine transport into the vesicle and thus blocks norepi in presynaptic terminals

27
Q

Asthma

A

Abuterol

28
Q

Open angle glaucome

A

Epinephrine, brimonidine, Causing myadriasis and allowing for improved flow of aqueous humor

29
Q

Over Active Bladder

A

Mirabegron (B3 agonist)

30
Q

ADHD

A

Methylphenydate (also increses dopamine)

31
Q

Cardiac Arrest

A

Epinephrine

32
Q

Cadiogenic Shock

A

Dobutramine (stimulate B1)

33
Q

Arrythmia

A
  • Phenylephrine (a agonist) through baroreflex

- Propranolol

34
Q

Hypertension

A

-Atenolol, Propranolo, Labetolol

35
Q

Congestive Heart Failure

A

Labetolol, Cavediol

36
Q

Angina Pecoris

A

-Propranolol

37
Q

Migrane Prophylaxis

A

Propranolol

38
Q

Recurrent MI

A

Metoprolol

39
Q

Glaucoma

A
  • Propranolol through decreased aqueous humor production
  • Ach agonist (carbachol)
  • Pilocarpine
40
Q

Tremor

A

Propranolol

41
Q

M1, M3, M5

A

Excititory Muscarininc Receptors

-Work through PLC to increase Ca

42
Q

M2 M4

A

Inhibitory Muscarninc

Decrease cAMP by decreasing AC activity

43
Q

Nm

A

Nicotinic on Muscle

44
Q

Nn

A

Nicotinic on Presynaptic ganglion

45
Q

Methacholin Bethanocol carbachol

A

Ach agonists

46
Q

Nicotine

A

Agonist for Nicotinic Receptors

47
Q

Atropine

A

Anatgonist for muscarninc Receptors

48
Q

edrophonium

A

short acting ACHesterase inhibitor

49
Q

Neostigmine Physostigmine

A

medium acting ACEsterase inhibitors

50
Q

Succinylcholine

A

Depolarizing Neuromusclular block
Strong Nm agoinst
Can cause malignant hyperthermia

51
Q

Tubocurarine

A

Nondepolarizing Neuromuscular block

NM Antagonist

52
Q

PANS functions

A

Constrict Bronchioles

53
Q

Muscarine

A

Muscarinic Agonist

From Flashcardlet (7 decks)

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