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Pharma101 > Autonomics > Flashcards

Autonomics Flashcards

1
Q

Betanechol MOA

A

activates Ach M3 receptors

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2
Q

Betanechol uses

A

for Bowel and Bladder atony

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3
Q

Betanechol side effects

A

Cyclospasm, Diarrhea, Urinary Urgency, reflex Tachycardia

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4
Q

Pilocarpine MOA

A

Activates Ach M3 receptors in cilliary muscles therefore increases aqueous humor outflow and salivary glands thus increasing salivation

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5
Q

Pilocarpine Uses

A

For glaucoma, sjogren syndrome and sicca syndrome

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6
Q

Pilocarpine Side effect

A

Miosis, Blurring of vision (due to cyclospasm)

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7
Q

Sjogren Syndrome

A

xerophthalmia (dry eyes)
xerostomia (dry mouth)
rheumatoid arthritis

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8
Q

Sicca Syndrome

A

xerostomia (dry mouth

xerophthalmia (dry eyes)

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9
Q

Varenicline(Nicotine) MOA

A

activates Nicotine Ach receptor (NN and Nm)

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10
Q

Varenicline uses

A

smoking cessation

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11
Q

Varenicline side effects

A

Generalized ganlionic stimulation ( hpn, tachycardia, nausea, vomiting, diarrhea)

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12
Q

Edrophonium MOA

A

inhibits acetylcholinesterase; Amplifies endogenously released acetylcholine

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13
Q

Edrophonium uses

A 
Myasthenia Gravis (diagnosis  Tensilon test)
differentiation of cholinergic crisis and myasthenic crisis
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14
Q

Edrophonium side effects

A

Miosis, Salivation, Nausea, Vomiting, Diarrhea, Bradycardia

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15
Q

Neostigmine/Physostigmine MOA

A

inhibits acetylcholinesterase, amplifies endogenously released acetylcholine

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16
Q

Neostigmine/physostigmine Uses

A

treatment for Myasthenia Gravis, glaucoma

17
Q

Rivastigmine MOA

A

inhibits acetylcholinesterase, amplifies endogenously released acetylcholine

18
Q

Rivastigmine uses

A

Alzheimer’s Disease

19
Q

Rivastigmine side effects

A

Miosis, Salivation, Nausea, Vomiting, Diarrhea, Bradycardia

20
Q

Atropine MOA

A

competitively blocks all muscarinic receptors

21
Q

Atropine uses

A

drug of choice antidote for Organophosphate poisoning

22
Q

Atropine side effects

A

Tachycardia, mydrisasis, cyclopegia, delirium, hallucination

23
Q

Pralidoxime MOA

A

binds phosphorous of organophosphate. breaks organophosphate bond with cholenesterase

24
Q

Pralidoxime uses

A

antidote for Organophosphate poisoning

25
Q

Pralidoxime side effects

A

muscle weakness

26
Q

Neostigmine/physostigmine Side effects

A

miosis, salivation, nausea, vomiting, diarrhea, bradycardia

27
Q

Benztropine MOA

A

competitively blocks all muscarinic receptors

restores neurotransmitter balance in the basal ganglia

28
Q

Benztropine uses

A

Parkinson’s Disease

29
Q

Benztropine side effects

A

blurring of vision, dry eyes, constipation, dry mouth, urinary retention

30
Q

Similar drugs of Benztropine for parkinson’s

A

Bipereden, Trihexyphenidyl

Pharma101 (1 decks)

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