B: 9-12

Question 1

Skeletal muscles acting on NMJ

Answer 1

Non deopl.-
אתה סיסי. מי בא במקום? כי כולכם מעלים היסטמין
Atracurium
Cisatracurium
Mivacurium
All increase histamine release and cause hypotension
Pancuronium is long acting. PANNN
Rocuronium hepatic metab. Rock in the liver
Pipecoronium is the most potent. Aslo antag at M2/3. Pipe is a long thing

Depol- Succinylcholine

Question 2

Succinylcholine MOA

Answer 2

Agonist at Ach nicotininc Nm-R
Resistant to AchE
Use for rapid things like intubation
SE malignant hyperthermia

Question 3

Direct acting muscle relaxant

Answer 3

Dantrolene- Ryanodine-R for malignant hyperthermia and NMS

Botulinum toxin- prevents synaptic exocytosis by inhibiting SNARE–>flaccid paralysis

Question 4

What drugs can cause malignant hyperthermia

Answer 4

Halothene

Succinyl choline

Question 5

Spasmatolytics

Answer 5

בוא תן בטיל דיאזפם
Baclofen- GABA-B agonist for motor output in spinal cord. Give in case of spasm due to cerebral palsy
Tolperisone- inhib. of stretch reflex
Diazepam- GABA-A agonist
Tizanidine- a2 agonist. Ms spasms

Question 6

Bronchial asthma and COPD drugs

Answer 6

SABA- Salbutemol, Terbutaline, Fenoterol
LABA- Formoterol, Salmeterol
B is before M So salbutemol shorter than Salmeterol
Ipratroium, Tiotropium- M3 antagonists
Methylxantine- Theophyline

Question 7

Methylxantine- Theophyline MOA

Answer 7

PDE inhib. –> increased cAMP –> bronchodialtion

Question 8

Anti inflammatory for asthma

Answer 8

Corticosteroids- Prednisone, Budesonide, Methyprednisolone, Fluticasone
LTD4 antag.- Monteleukast
Anti IgE Ab- Omalizumab. Last resort

Question 9

Antitussive

Answer 9

Codeine for cough reflex
Butamirate- non opioid
Acetylcyteine- sputum excretion. reduce sulfide bonds in mucus–>less viscosity
Bromhexidine- more serous fluid so less viscous

Cystif fibrosis!
Prenoxdiazine- desensitizing stretch receptors so less cough impulse. For cough due to bronchial origin