BAP lab 4 - repurposing medicines

Question 1

what is drug repurposing ?

Answer 1

Also known as drug repositioning, re-profiling, re-tasking is a ‘drug development’ strategy predicated on the reuse of existing licensed drugs for new medicalconditions/symptoms.

Achieved by investigation of existing drugs for new or alternative therapeutic purposes – especially in area of rare and neglected diseases

Question 2

why do we repurpose drugs?

Answer 2

Risk of failure is low as drug already proved to be safe and effective - Shorter time frame to market as all pre-clinical testing already done.

Question 3

how can we repurpose drugs?

Answer 3

Previously mainly opportunistic – “off target” effect or side effect which is manipulated to become the main, therapeutic effect.

Question 4

what is the process drug follow fro repurposing?

Answer 4

phenotypic of computational screening data, drug, in silicon screening, in vitro screening and pre clinical trolls, in vivo screening, clinical trolls., PDA approval and successful drug repurposed

Question 5

what are examples of drug that have been repurposed?

Answer 5

minoxidil
thalidomide
topiramate
raloxifene
sildenafil