BBB Flashcards
1
Q
what do astrocytes form (Structure)
A
perivascular sheets - end feet
glia-limitans
2
Q
5 astrocyte functions
A
- energy and nutrients - neurones
- brething - senseCO2 and O2 in ISF
- ion and water homeostasis
- maintain BBB
- terminate synaptic activity
3
Q
what junctions are present in paracellular movementn
A
adnerens
tight
4
Q
adhering proteins
A
PECAM
Vasicular-endothelial (VE) -cadherin
5
Q
what proteins are in tight junctions
A
JAMs and ESAM
connect to actin cytoskeleton via ZO-1,2,3
claudin 3,5,12
occludin
6
Q
what is involved in active efflux mechanism in brain
A
atp-binding cassette
ABC transorters
e.g. P-glycoprotein
7
Q
types pf ABCs - efflux
A
- P-glycoproteins - lipophilic molecules neu/cationic
- breast cancer resistance protein BCRP
- milti-drug resistnce associated protek MRP
