Benign and malignant disease Flashcards
What is the definition of a fibroadenoma?
Hyperplastic or proliferative process in a single terminal ductal unit stromal and glandular tissue
When are cysts most common?
4th and 5th decade
What can be the causes of traumatic fat necrosis?
Can be iatrogenic or can be caused by blunt force trauma due to breakdown of adipose tissue
What is a Phyllodes tumour? How do they present?
Rare tumour that tends to occur in women between 40-50. Arise from stromal cells, sarcoma. Can be benign, borderline or malignant.
Firm mobile well circumscribed, non-tender breast mass, similar to fibroadenoma.
What are the signs and symptoms of periductal mastitis?
Peri areola: pain, discharge, nipple changes, signs of cellulitis, subareolar mass, may be associated with a mammary duct fistula
What is the most common causative agent of acute bacterial mastitis?
Usually associated with lactation and staph aureus infection and abscess
What is the most common type of breast carcinoma?
Ductal
What are the 4 types of invasive breast cancer?
Lobular, tubular, medullary and mucinous
What is Paget’s disease of the breast?
A ductal carcinoma (either in situ or invasive) of the secretory ducts with early infiltration of the nipple and areola. Patients present with a scaly erythematous rash of the nipple and areola.
What is the MOA of tamoxifen?
Selective oestrogen receptor modulators
What is the MOA of anastrazole?
Aromatase inhibitors (used in post-menopausal women)
What is the MOA of trastuzumab?
Monoclonal antibody specific for Her2/Neu receptor
