bio final exam Flashcards
what are the three phases of general adaptation syndrome
alarm
adaptation
exhaustion
alarm reaction
initial response to stress
adaptation
includes activation of appropriate responses systems and reestablishment of homeostatic balance
exhaustion
occurs when stress is prolonged or severe
where is info from the HPA axis conveyed
PVH or paraventricular nucleus of the hypothalamus
corticotropin releasing factor
synthesized and secreted by neurons in the PVH
adrenocorticotropic hormone (ACTH)
what the cells in the anterior pituitary synthesize and secrete into the bloodstream
ACTH stimulates the release of what from the adrenal cortex
cortisol
what does cortisol do
increases blood sugar by activating metabolism
catabolizes fat and proteins
after the stressor ends cortisol feeds back into the brain to shut off HPA axis
prolonged cortisol from HPA hyperactivity may inhibit what
growth hormone release
what causes synapse loss in the hippocampal and prefronta cortical pyramidal neurons
prolonged elevations in corticosterone
three types of depression
colloquial
reactive depression
major depressive disorder
colloquial depression
superficial, temporary sadness
reactive depression
due to a bad life event
usually resolves itself within 6 months
major depressive disorder
severe depression, prolonged
post partum depression
depression after childbirth
MDD
what u have bitch
extreme feelings of sadness everyday for weeks
MAO (monoamine oxidase)
a presynaptic enzyme that degrades neurotransmitters into metabolites
MAO inhibitor
blocks MAO activity and prevents the breakdown of MA neurotransmitters
monoamine hypothesis for depression
depression is caused by low 5HT and NE neurotransmitter activity