Book Questions Flashcards
A 60yr old female referred to a dermatologist by her primary care physician becasue of a pain-less, inflamed, erupting ulcer that has been on her right hand for two months. THis patient works in her vegetable and herb garden daily and states that the lesion began as a small red papule. Despite 10days of tx with cephalexin, the papule has continued to enlarge. The dermatologis cultured the ulcer and the results demonstrated the patient has sporotrichoisis and infection caused by sporothrix schenckii. WHat i sthe most appropirate therapy?
Itraconazole
DOC for treatment of sporotrichosis. It is well absorbed orally.
47yr old female is admitted to the hospital for treatment of a candida infection. Upon obraining a medical history from the pt, the practinioner learns that the pt has had a liver transplant and is taking cyclosporine to avoid organ rejection. What intravenous antifungal agent would avoid any potential drug interaction or potential toxicities of concomitant adminstartion with cyclosporine yet provide and efficacious treatment for candida infection?
Micafungin. Efficacious against candida and no interactions with cyclosporin
A 22yr old male has been treating his athletes foot with an OTC drug without much success. Upon examination, it is found that the nail bed of both great toes is infected. Which anti-fungal is most appropriate?
Terbinafine is the DOC for treatment of dermatophytic infections
-it is fungicidal and requires shorter course of therapy
A 36 yr old male of Lebanese ancestry is being treated for Plasmodium vivax malaria. He experiences severe fatigue, back pain, and darkened urine. WHich of th efollowing antimalarial drugs is most likely to have cuased his sx?
His sx are consistant with hemolytic anemia.
Primaquine is most likely to cause hemolytic anemia
Tinnitus, dizziness, blurred visino and headache are indicative of toxicity of which malarial drug?
These symptoms are consistant with cinchonism. This is a characteristic of quineine or quinidine.
other drugs do not cause these symptoms
Which drug is recommended for the treatment of severe multidrug-resistant Plasmodium Falciparum malaria?
Artemisinin is the antimalarial drug recommended for life threatening, multi drug resistant plasmodium falciparum malaria.
A 22yr old man whe frequently backpacks, complains of diarrhea and fatigue. Examination of stool specimans shows binucleate organisms with four flagellae. Which drug should be used to treat?
The patient has giardiasis. the DOC is metronidazole.
What is the appropriate combination of antiparkinsons drugs?
Levodopa, carbidopa and entacapone
Dopamine agonist
decaboxylase inhibitor
catechol-O-methyltransferase (COMT)
Peripheral adverse effects of levodopa, including nausea, hypotension and cardiac arrhythmias can be diminished by including what drug in therapy?
Carbidopa. Inhibits the peripheral decarboxylation of levodopa to dopamine.
What anti-parkinson drug also causes peripheral vasospasm?
Bromocriptine, it is a dopamine receptor agonist that may causes vasospasm.
It is contraindicated in patinets with peripheral vascular disease.
Modest improvement in the memory of patients with alzheimer’s disease may occur with drugs that incrase transmission at which receptor?
Cholinergic receptors
Acetylcholinesterase inhibitors such as rivastigmine, increase cholinergic transmission in the CNS and may cause a modest delay in the progression of Alzheimers disease.
True or False, All bensodiazepines have some seative effects?
True
True or False Bensodiazepines directly open choloride channels?
False. It is indirect through the binding of y-aminobutyric acid to its receptor that increases permeability
T or F Benzodiazapines show analgesic actions
They do not reduce pain but decrease anxiety associated with pain
T or F Benzodiazapines show clinical improvement of axiety in 2-4 weeks
False effective within hours of administrations
