BRAIN Flashcards
inadequate oxygen in body tissue
hypoxia
inadequate blood supply in body tissue
ischemia
the medical condition of having an
unusually low level of sugar in the blood
hypoglycemia
hyperglycemia
the medical condition of having an unusually high
level of sugar in the blood
Ischemia Morbid Neurological Outcomes
Type 1 Types?
Cerebral Death
Non-fatal strokes
New TIA’s
Ischemia Morbid Neurological Outcomes
Type 2 Types?
New intellectual deterioration
New seizures upon discharge
Type I Predictors (4)
Advanced age
Aortic atherosclerosis
History of prior neurologic events–15%
Carotid stenosis
Type 1 Predictor Advanced age % risks
Advanced age
Independent of other factors predisposes to stroke
< 60 : 1% risk
> 70 : 4 to 9% risk
Type II Predictors (6)
Low cardiac output states Atrial arrhythmias Systolic Hypertension Diabetes Pulmonary Disease Excessive Alcoholism
Neuro Impairment
6.1% - prevalence of CVS complication
Stroke, stupor, coma, deterioration in intellectual function, memory deficit or seizures
Post-Op Delirium
10-60% prevalence of CVS complication
Depending on patient age and type of surgery
These patients have an LOS of 20-25 days vs. 10 days for patients with no adverse outcomes
Post-Op Delirium LOS?
Patients have an LOS of 20-25 days vs. 10 days for patients with no adverse outcomes
Incidence of Neurologic Dysfunction
Permanent complications %
1.6 - 23%
Perfusion Contributes Focal
Embolism Types
Air Plaque Microemboli Left ventricular thrombus Fat Debris
Ischemia Reperfusion Injury
potent triggers for: activation of leukocyte, leukocyte-endothelial or leukocyte endothelial platelet binding
Tailoring Oxygen Delivery
HOW?
Mean Arterial Pressure CO2 Cardiac Index and Pump Flow Hematocrit Mechanical Issues
Tailoring Oxygen Consumption
HOW?
- Anesthetic Agent and Depth
* Temperature
Detection of cerebral ischemia and administration of pharmacologic agents to provide cerebral protection depend on:
accurate, reliable monitoring of cerebral
electrical activity
ICP
Intra-cranial pressure monitoring
type of brain monitoring
rSO2
Regional Saturation of Oxygen
type of brain monitoring
TCD
Transcranial Doppler
type of brain monitoring
BIS
Bispectral Index
type of brain monitoring
SjVO2
Saturation of Jugular Venous Oxygen
type of brain monitoring
Invivo Optical Spectroscopy
INVOS Somanetics Cerebral Oximetry
type of brain monitoring