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Chemo > Breast CA > Flashcards

Breast CA Flashcards

1
Q

Breast cancer involving ducts

A

Ductal carcinoma

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2
Q

Breast cancer involving lobes

A

Lobular carcinoma

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3
Q

Breast cancer with a visible tumor/redness

A

Inflammatory breast cancer

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4
Q

Risk Factors

A 
Early Menstruation
Family history
Alcohol
Hormones
Obesity
Radiation therapy to the breast/chest
Dense tissue in mammogram
Exercise not enough
Older age at first birth/never giving birth
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5
Q

Signs

A 
Thickening/lump
Size change
Dimple/puckering
Nipple inversion
Fluid discharge(blood)
Scaly,red, or swollen skin
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6
Q

Types of breast exam

A

Self

Clinical

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7
Q

Detection

A 
Breast exam
Mammogram
Ultrasound
MRI
Blood Chem
Biopsy
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8
Q

Biopsy type: removal of entire lump of tissue

A

Excisional

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9
Q

Biopsy type: removal of a part of a lump or sample of tissue

A

Incisional

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10
Q

Biopsy type: uses a wide needle

A

Core Needle biopsy

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11
Q

Biopsy type: uses a thin needle

A

Fine needle aspiration(FNA)

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12
Q

Additional tests after (+) result for breast CA

A 
Estrogen and progesterone receptor
Human epidermal growth factor Type 2 receptor(HER2/neu)
↑levels=cancer may grow quicker
Sentinel lymph node biopsy
Bone scan
CXR
CT
PET scan
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13
Q

noninvasive condition with abnormal cells

A 
Staging breast CA:
In situ
Ductal
Lobal
Pagets disease in the nipple
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14
Q

•Tumor is ≤ 2cm

A

Stage IA

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15
Q

•(0.2 – 2 mm) cancer in LN ± Tumor ≤2 cm

A

Stage IB

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16
Q
  • (>2mm) cancer in 1-3 LN ± tumor (≤ 2cm)

* Tumor (2-5 cm) no lymph node

A

Stage IIA

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17
Q
  • (0.2 – 2 mm) cancer in 1-3 lymph nodes + tumor (2-5 cm)

* Tumor (>5 cm) no lymph node

A

Stage IIB

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18
Q
  • Cancer in 4-9 lymph nodes ± tumor (any size)

* (0.2 – 2 mm) cancer in 1-3 lymph nodes + tumor (>5 cm)

A

Stage IIIA

19
Q

•Cancer in 9 lymph nodes, chest wall, breast skin ± tumor

any size

A

Stage IIIB

20
Q

• Cancer in >10 lymph nodes, chest wall, breast skin ± tumor

any size

A

Stage IIIC

21
Q

•Spread to other organs

A

Stage IV

22
Q

I
II
IIIA
IIIC operable

A
  • Surgery
  • Adjuvant therapy:
  • Radiation therapy
  • Chemotherapy ± hormone therapy
  • Hormone therapy
  • MAB + chemotherapy
  • Clinical trials
23
Q

IIIB
IIIC inoperable
IV
Metastatic

A
  • Chemotherapy → surgery
  • Additional therapy:
  • Chemotherapy
  • Hormone therapy
  • Clinical trials
24
Q

A

A

Doxorubicin(Adriamycin)

25
Q

C

A

Cyclophosphamide

26
Q

E

A

Epirubicin

27
Q

F

A

Fluorouracil

28
Q

M

A

Methotrexate

29
Q

T

A

Paclitaxel(Taxol)

30
Q

Chemotherapy for breast CA

A 
AC
ACT
CAF
CMF
FEC
31
Q

Increase risk of Breast CA

A

Postmenopause

Tx: Hormones= higher post menopausal survival

32
Q

Gold standard for estrogen sensitive tumors

A

Tamoxifen

33
Q

Aromatase inh

A

Letrozole
Exemastane
Anastrozole

34
Q

Aromatase inh ADR

A

Bone fracture

CV complications 3

35
Q

MAB that blocks the effects of growth factor protein HER2

A

Trastuzumab

36
Q

treat HER2 positive metastasis

A

Pertuzumab

37
Q

Tyrosine kinase inh that blocks PROTEINS(HER2 and others) inside tumor cells

A

Lapatinib

38
Q

Prognosis of Breast CA

A

months to 2 years

39
Q

Metastasis of breast CA

A

lung to bone

40
Q

has better prognosis with hormone therapy

A

BONE METASTASIS

41
Q

On relapse

A

INCREASE DOSE or

CHANGE PROTOCOL

42
Q

Chemotherapy for Metastatic Breast CA

A 
Doxo/epirubicin, taxanes
Vinorelbine
Taxanes and Capecitabine
Gemcitabine
Bevacizumab-VEG +/HER2 negative
43
Q

Adjunct to Metastatic

A

Biphosphonate:

Alendronate

Chemo (3 decks)

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