Breast cancer

Question 1

What is the triple assessment in Breast cancer?

Answer 1

• Clinical exam of breasts and surrounding lymph nodes
• Radiological imaging: USS (if premenopausal) and Mammography if (post menopausal)
• Biopsy

Question 2

What are the three main hormonal types of breast cancer?

Answer 2

ER (oestrogen receptor)
HER2 (human epidermal growth…)
PR (Progesterone receptor)

Question 3

What is the treatment for ER +ve?

Answer 3

Tamoxifen (if premenopausal)

Anastrazole (if postmenopausal)

Question 4

Treatment for HER2 +ve?

Answer 4

Trastuzumab

Question 5

What are the genes associated with Breast cancer?

Answer 5

BRCA1 & BRCA2

Question 6

What is the most common form of breast cancer?

Answer 6

Ductal carcinoma

Question 7

Most common type of breast cancer in young patient with BRCA1 mutations?

Answer 7

Medullary carcinoma

Question 8

Which type of breast cancer is composed of epithelial and stromal tissue and grows in a “leaf-like” pattern?

Answer 8

Phyllodes tumour

Question 9

What age group is the breast screening programme? How regular is it?

Answer 9

Aged 50-70

Every 3 years

Question 10

What type of surgery for breast cancer?

Answer 10

WLE if solitary lesion and well isolated
Sentinel node biopsy in most procedures
Axillary node clearance if positive nodes on SNB

Mastectomy for larger/more invasive cancers

Radiotherapy give as adjuvant to most surgeries as helps reduce reoccurrence

Question 11

Which hormonal management for Hormone +ve breast cancer increases likelihood of endometrial cancer?

Answer 11

Tamoxifen