BS42025 L1,2,3

Question 1

what is the most common IV clinical anaesthetic used?

Answer 1

propofol

Question 2

what common feature do all general anaesthetics share?

Answer 2

they are all lipid soluble so will dissolve across the neural membrane

Question 3

which IV anaesthetics increase GABA-ergic inhibition?

Answer 3

etomidate, propofol, alphaxalone, pentobarbitone

Question 4

the effects of etomidate is dependent on which subunit?

Answer 4

B subunit (B2 and 3 enhances function, B1 has no effect)

Question 5

which amino acid is responsible for the actions of etomidate in B-subunits

Answer 5

asparagine in position 265 (B2,3) serine (B1)

Question 6

where is the binding site for etomidate and propofol?

Answer 6

between B2 and A1 interface

Question 7

what effect does etomidate have?

Answer 7

sedative effect

Question 8

how would you record neurones in brain slices from wt mice or from the b mutant mice?

Answer 8

whole-cell voltage-clamp technique

Question 9

what brain regions are implicated in the effects of general anaesthetics?

Answer 9

thalamus and connections to the cortex