Bugs & Drugs: Cephalosporins

Question 1

What is the MOA of Cephalosporins

Answer 1

Bactericidal: inhibits bacterial cell wall synthesis via competitive inhibition of the transpeptidase enzyme

Question 2

CeFAzolin, CePHalexin, CeFAdroxil are all

Answer 2

1st generation Cephalosporins

Question 3

Brand name for Cefazolin

Answer 3

Ancef

Question 4

Brand name for CePHalexin

Answer 4

Keflex

Question 5

Brand name for Cefadroxil

Answer 5

Duricef

Question 6

What are the two 1st generation cephalosporins given by mouth

Answer 6

CePHalexin- Keflex
CeFAdroxil-Duricef

Question 7

The only first generation cephalosporins given by IV

Answer 7

Cefazolin- Ancef

Question 8

Do 1st generations have gram positive coverage

Answer 8

Yes. streptococcus & Staph (MSSA)

Question 9

Do first generations have gram negative coverage

Answer 9

Yes. PEcK

Question 10

What is the drug of choice for MSSA

Answer 10

first generation cephalosporins: chephalexin: Keflex(PO) Cefazolin: Ancef(IV)

Question 11

What are the second generation Cephalosporins

Answer 11

CEFoxitin
CEFotetan
CEFaclor
CEFprozil
CEFuroxime

Question 12

Which three 2nd generation are given IV

Answer 12

Cefoxitin
Cefotetan
CEFuroxime

Question 13

Which two 2nd generation cephalosporins are given by mouth

Answer 13

Cefaclor
Cefprozil

Question 14

Which are the only two cephalosporins that cover anaerobes

Answer 14

Cefoxitin and Cefotetan

Question 15

Do 2nd generation cephalosporins have gram positive coverage

Answer 15

Yes. But not as much as gram positive

Question 16

Do 2nd generation cephalosporins have Gram negative activity

Answer 16

Yes. HEN-PEck

Question 17

What are the 3rd Generation Cephalosporin

Answer 17

CefriaxONE
CefotaxIME
CeftazidIME
CefdiNIR
CefixIME
CefpodoxIME
CeftibuTEN

Question 18

Brand name for Cefdinir

Answer 18

Omncicef

Question 19

All 3rd generation cephalosporins can be given by mouth, except

Answer 19

CefriaxONE(IV)
CefotaxIME (IM)
CeftazidIME (IV)

Question 20

Are 3rd generation cephalosporins good on staph

Answer 20

Not so much but can cover it. Not good as 1st and 2nd

Question 21

What is the ONLY 3rd gen. cephalosporins that covers Pseudomonas aeruginosa

Answer 21

CeftazidIME

Question 22

Do 3rd gen have better Strept coverage than gen 1 & 2

Answer 22

Yes. Better coverage

Question 23

What spectrum of gram negative coverage do 3rd generation cephalosporins have

Answer 23

Broad coverage

Question 24

What is the only 4th generation cephalosporins

Answer 24

Cefepime

Question 25

Is Cefepime given IV or PO

Answer 25

IV

Question 26

Does Cefepime cover Pseudomonas aeruginosa

Answer 26

Yes

Question 27

Does Cefepime cover MSSA or MRSA

Answer 27

MSSA

Question 28

Cefepime has both gram + and gram - coverage

Answer 28

Yes. Broad spectrum

Question 29

What is the only 5th gen. Cephalosporin

Answer 29

Ceftaroline

Question 30

Ceftaroline is given

Answer 30

IV

Question 31

Ceftaroline can cover MRSA and pseudomonas

Answer 31

No just MRSA

Question 32

Ceftaroline is the only cephalosporin with MRSA coverage

Answer 32

Yes

Question 33

Ceftaroline has both gram + and gram - coverage

Answer 33

Yes

Question 34

What are the cephalosporin/BLI combos

Answer 34

CeftazidIME/avibactam
Ceftolozane/tazobactam

Question 35

Brand name for CeftazidIME/avibactam

Answer 35

Avycaz

Question 36

Brand name for ceftolozane/tazobactam

Answer 36

Zerbaxa

Question 37

What do Cepha/BLI combos cover

Answer 37

MSSA
Strept
Broad gram -
Pseudomonas
Some carbapenem resistant bacteria

Question 38

When should cepha/BLI combo be used

Answer 38

Reserved for multi-dose resistant gram negative infections