Flashcards in Bunyavirus & Arenavirus Deck (15):
SUPERGROUP! includes 200+ enveloped segmented ssRNA
most are arboviruses (arthropod)
envelope has 2 proteins G1 &G2
has 3 ssRNA
Viremia, secondary viremia, and target sites such as CNS, Liver, Kidney, vascular endothelium
Induce type 1 interferons
Usually mild nonspecific febrile, flulike, viremia related illness. fever ~ 3 days
~1 week incubation, fever, headache, lethargy, vomiting,
Seizures, meningitis, <1% death.
Hemorrhagic fevers (rift valley fever)
Hantavirus: pulmonary syndrome. resp failure.
RT-PCR on viral RNA
ELISA may detect antigen in clinical specimens with intense viremia
no specific therapy.
kill mosquitos and rats(hantavirus)
Hemorrhagic fever viruses: Lassa, Junin, Machupo.
enveloped virion, 2 circular ambi-ssRNA
infect macrophages, induce cytokine + interferon. cell and vascular damage.
T cell immunopathies
Africa + South America
zoonosis via rodents
infect humans through: inhalation of aersols, contaminated food, fomites. (not usually bites)
Arena LCMV symptoms
Febrile + flulike myalgia
10% progress to CNS
perivascular mononuclear infiltrates
Arena Lassa and other hemorrhagic fevers symptoms
Fever(duh), coagulopathy, petechiae,
liver and spleen necrosis.
hemorrhage and shock.
occasional cardiac and liver damage.
death in 50%
RT-PCR for viral genome.
too dangerous for isolation
level3 for LCM
level 4 for Lassa + others
Ribavirin (of course)
supportive therapy (so nothing really)
don't touch rats.