CAMs

Question 1

What are the two calcium independent CAMs?

Answer 1

integrins and immunoglobulin superfamily

Question 2

intermediate protein that links cadherins to actin of the cytoskeleton

Answer 2

catenin

Question 3

CAM that binds neighboring cells together, calcium dependent

Answer 3

cadherin

Question 4

three classical kinds of cadherins

Answer 4

E cadherins (epithelial)
N cadherins (neural)
P cadherins (placenta)

Question 5

these CAM bind to carbohydrates at CRD extracellularly with the help of calcium and help leukocytes get from the blood to tissues

Answer 5

selectins

Question 6

three classes of selectins

Answer 6

P (platelets)
E (endothelial)
L (leukocytes)

Question 7

this CAM binds extracellularly to fibronectin and laminin (basement membrane or extracellular membrane) at the RGD sequence

Answer 7

integrin

Question 8

these CAMs have an extracellular component. the two classees are N CAM and I CAM

Answer 8

n cam- neural adhesion
i cam- mediate leukocyte migration
IMMUNOGLOBULIN SUPERFAMILY

Question 9

characteristics of epithelium (9)

Answer 9

• it is composed majorly of cells (very little matrix)
• arranged in sheets
• covers/lines/protects/secretes
• has a free surface (apical) and bound sides (basolateral)
• is polar
• receives blood by diffusion (not vascularized)
• innervated
• tightly bound by junctions
• regenerative (mitotically active)

Question 10

2 components of basement membranes

Answer 10

basal lamina and reticular lamina

Question 11

basal lamina is composed of what

Answer 11

laminin, fibronectin, type IV collagen, entactin, proteoglycans

Question 12

this layer of the basement membrane is in contact with underlying connective tissue, it’s made of reticular fiber and glycoproteins

Answer 12

reticular lamina

Question 13

what are the 3 categories of junctional complexes in epithelial cells

Answer 13

adherins, occludens, gap junctions

Question 14

this junctional complex anchors cells together to reinforce the tissue integrity (and is associated with cadherin filled junctions)

Answer 14

adherin

Question 15

this type of junctional complex is also known as a tight junction because it creates an impermeable barrier between cells that prevents transport to maintain concentration gradients

Answer 15

occludens

Question 16

gap junctions

Answer 16

composed of pores called CONNEXONS (made of 6 connexins) to allow ion/ small molecule exchange between cells

Question 17

this junctional complex can be of adherin or occluden variety

Answer 17

zonula

Question 18

this junctional complex is a belt like junction (wraps all the way around cell) that associates with intracellular actin

Answer 18

zonula

Question 19

this junctional complex is of the adherins family and is a “snap like junction” that associates with intracellular intermediate filaments

Answer 19

macula (aka desmosome on lateral surface or hemidesmosome on basal surface)

Question 20

This junctional complex mediates adherin junctional complexes.

Answer 20

cadherins (desmoglein in the epidermis or desmocollins)

Question 21

disease attacking desmoglein of epidermis causing dissociation of layers and blistering

Answer 21

pemphigus foliaceus

Question 22

What are the 2 classes of calcium dependent CAM’s?

Answer 22

Cadherins and selectins