Cancer Genetics L8

Question 1

All Cancers are due to what type of mutation?

Answer 1

DNA mutaiton

Question 2

Predisposition is inherited as ________

Answer 2

Autosomal Dominant

Question 3

What is the knudson’s 2-Hit hypothesis?

Answer 3

Cancer cell may emergy via accumulation of several independent gene mutations

Question 4

What is loss of function?

Answer 4

Most common in germline predisposition

Require mutation in both alleles of same gene

Question 5

Name two examples of LOF

Answer 5

Tumor supressors and DNA mismatch

Question 6

What is gain of function?

Answer 6

Less often caused by inherited predisposition

Loss of second allele is not required

Question 7

Name an example of GOF

Answer 7

Oncogenes

Question 8

Name red flags for HEREDITARY cancers

Answer 8

1. Early onset (<50)
2. Multiple or bilateral tumors
3. Rare or unusual tumors
4. Combo. of certain cancers
5. A.D. pattern of inheritance
6. Lack of known contributing factors

Question 9

Name red flags for BRCA

Answer 9

1. Early onset (<40/50)
2. Bilateral Breast Cancer
3. Male Breast Cancer
4. Jewish Descent
5. Combo. of breast, ovarian, pancreatic
6. Families with known BRCA